Results 51 to 60 of about 129,294 (348)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

From pixels to patrol cars: exploring desktop-based simulator sickness in police driving training

Frontiers in Virtual Reality
Simulator sickness (SS) poses significant challenges in the widespread adoption of driving simulators for traffic research, training, and other applications.
Joakim Ingrell, Caroline Mellgren
doaj   +1 more source

Validation of a Driving Simulator for Research Into Human Factors Issues of Automated Vehicles

Journal of Road Safety, 2019
This study evaluated the behavioural validity of the Monash University Accident Research Centre automation driving simulator for research into the human factors issues associated with automated driving.
Nebojsa Tomasevic, Tim Horberry, Kristie Young, Brian Fildes   +3 more
doaj   +1 more source

Further development of a commercial driving simulation for research in occupational medicine

International Journal of Occupational Medicine and Environmental Health, 2013
Objectives: The purpose of this study was to refine a commercial car driving simulation for occupational research. As the effects of ethanol on driving behavior are well established, we choose alcohol as a test compound to investigate the performance of ...
Axel Muttray, Anais Breitinger, Elisabeth Goetze, Thomas Schnupp, Britta Geissler, Thomas Kaufmann, Martin Golz, Stephan Letzel   +7 more
doaj   +1 more source

Manual control analysis of drug effects on driving performance [PDF]

, 1981
The effects of secobarbital, diazepam, alcohol, and marihuana on car-driver transfer functions obtained using a driving simulator were studied. The first three substances, all CNS depressants, reduced gain, crossover frequency, and coherence which ...
Moskowitz, H., Smiley, A., Ziedman, K.
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Designing an Augmented Reality in-car Driving Simulator

Journal of Computing Research and Innovation, 2018
This paper demonstrates the design of augmented reality (AR) in-car driving simulator system architecture and its experimental design. AR in-car driving simulator is developed in order to explore its effect towards subjects' simulator sickness when ...
Haryati Fauzi, Aznoora Osman, Muhammad Arif Hashim, Ahmad Hanif Ahmad Baharin   +3 more
doaj  

What, Who, and When? The Perceptions That Young Drivers and Parents Have of Driving Simulators for Use in Driver Education

Safety, 2020
Driver education providers may utilise technologies such as driving simulators to augment their existing courses. Understanding the perceptions that young drivers and parents have of simulators may help to make simulator-based driver education more ...
David Rodwell, Grégoire S. Larue, Lyndel Bates, Narelle Haworth   +3 more
doaj   +1 more source