Results 71 to 80 of about 2,359,063 (339)

Validation of Vehicle Driving Simulator from Perspective of Velocity and Trajectory Based Driving Behavior under Curve Conditions

open access: yesEnergies, 2021
With their advantages of high experimental safety, convenient setting of scenes, and easy extraction of control parameters, driving simulators play an increasingly important role in scientific research, such as in road traffic environment safety ...
Liang Chen   +5 more
doaj   +1 more source

Assessing the Influence of Adverse Weather on Traffic Flow Characteristics Using a Driving Simulator and VISSIM

open access: yesSustainability, 2019
The occurrence of adverse weather exacerbates traffic flow conditions, often leading to severe traffic congestions. Many studies have been conducted based on field-collected data to obtain the effects of weather on traffic flow characteristics.
Chen Chen   +5 more
semanticscholar   +1 more source

A Training Oriented Driving Simulator [PDF]

open access: yes, 2007
In today's China, a growing number of people have the opportunity to have their own cars. This creates tremendous requirement of training of new drivers. At the same time, recent advances in Computer Graphics and Virtual Reality system have brought the new opportunities for the development of driving simulation. This paper describes a driving simulator
Chao Sun   +4 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Designing an Augmented Reality in-car Driving Simulator

open access: yesJournal of Computing Research and Innovation, 2018
This paper demonstrates the design of augmented reality (AR) in-car driving simulator system architecture and its experimental design. AR in-car driving simulator is developed in order to explore its effect towards subjects' simulator sickness when ...
Haryati Fauzi   +3 more
doaj  

Validation of a Driving Simulator for Research Into Human Factors Issues of Automated Vehicles

open access: yesJournal of Road Safety, 2019
This study evaluated the behavioural validity of the Monash University Accident Research Centre automation driving simulator for research into the human factors issues associated with automated driving.
Nebojsa Tomasevic   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Further development of a commercial driving simulation for research in occupational medicine

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2013
Objectives: The purpose of this study was to refine a commercial car driving simulation for occupational research. As the effects of ethanol on driving behavior are well established, we choose alcohol as a test compound to investigate the performance of ...
Axel Muttray   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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