Results 41 to 50 of about 270 (196)

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

ROLLER COMPACTED CONCRETE RCC UNTUK BANGUNAN BENDUNGAN

Civil Engineering Dimension, 2003
The using of Roller Compacted Concrete (RCC) is one of many alternatives that can be used to decrease dam construction cost. Many Roller Compacted Concrete (RCC) composition has been developed to achieve maximum compressive strength.
Handoko Sugiharto, Henry James, Deddy Hardianto, Ruslan Djajadi   +3 more
doaj  

A Variable-Impulse Hammer Impact Test (VIHIT) Method for Improved Mode Shape Identification

Sensors
The impact hammer, equipped with a force transducer, is a portable and practical tool for inducing measurable excitations in structural health monitoring (SHM). However, its reliability is often limited by uncontrolled factors such as swing power, angle,
Alec Jensen, Charles Riley
doaj   +1 more source

Research on Dynamic Pile-Driving Formula Parameters and Driving Feasibility of Extra-Long PHC Pipe Piles

Buildings, 2023
Prestressed high-strength concrete (PHC) pipe pile has the advantages of high single pile bearing capacity, a wide range of applications, good driving resistance, fast construction speed, etc.
Xiaomin Liu, Yonggang Xiao, Junlong Zhou, Longbo Ge, Ziwen Song   +4 more
doaj   +1 more source

Unifying Composition and Process Design: A Heterogeneous Graph Neural Network for Discovering High‐Performance Cu Alloys

Advanced Science, EarlyView.
By overcoming the fixed‐path limitations of conventional machine learning, a heterogeneous graph neural network fundamentally reconstructs material data representation. Integrating variable processing sequences with intrinsic elemental features, this framework enables exploratory optimization across high‐dimensional spaces.
Jie Yin, Qian Lei, Wei Yan, Yue Li, Tong Xie, Shuang Zhou, Chong Wang, Bram Hoex, Qiang Long, Caoyang Jiang, Min Song, Zhou Li, Zhangwei Wang   +12 more
wiley   +1 more source

Prediction of Impact Response for Reinforced Concrete Beams by Numerical Simulation Method [PDF]

Journal of Rehabilitation in Civil Engineering
Brittle characteristics, low tensile strength, and rapid crack propagation upon exposure to impact loads are some of the issues associated with concrete.
Ahmad Rahmati Alaei, Seyed Mohammad Hossein Khatami   +1 more
doaj   +1 more source

Evaluation of measurement uncertainty of drop hammer impact test for composite materials

Journal of Physics: Conference Series
Abstract Future aircraft structures are usually dominated by composites, and one of the key defects and forms of damage to composite structures is the impact damage caused by low-energy (especially low-speed) foreign matter. This kind of low-energy impact test is usually completed by the drop hammer testing machine, so accurately ...
Li Lei, Zhang Yao
openaire   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Cicada Wing‐Inspired Skeleton‐GO Networks in Melamine Foams for Multifunctional High‐Performance Composites

Advanced Science, EarlyView.
Inspired by the intricate microstructure of cicada wings, researchers developed a novel in situ skeleton‐graphene membrane architecture within lightweight foams. This bioinspired design dramatically enhances multifunctional performance: vibration attenuation time decreases by ∼83.3%, damping capacity increases by ∼179.3%, and compressive modulus rises ...
Jigang Feng, Anhao Li, Babak Safaei, Yun Kong, Yizhen Miao, Zhaoye Qin, Fulei Chu   +6 more
wiley   +1 more source