Results 61 to 70 of about 500,205 (299)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Droplet collision of hypergolic propellants

Droplet
In the present mini‐review, droplet impacting on a liquid pool, jet impingement, and binary droplet collision of nonreacting liquids are first summarized in terms of basic phenomena and the corresponding nondimensional parameters.
Chengming He, ZhiXia He, Peng Zhang
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Actuating droplets with electrowetting: Force and dynamics

Droplet
Electrowetting on dielectric (EWOD) allows rapid movement of liquid droplets on a smooth surface, with applications ranging from lab‐on‐chip devices to micro‐actuators. The in‐plane force on a droplet is a key indicator of EWOD performance.
Robert Hennig, Vito Cacucciolo, Herbert Shea   +2 more
doaj   +1 more source

Preparation of nano‐pico droplets using an open fibrous system

Droplet, 2023
Manipulation and dispensing of ultra‐tiny droplets have attracted extensive research attention for their applications. Current approaches for dispensing liquids normally involve the use of micronozzles and microtips, which, however, suffer from ...
Bojie Xu, Xuan Chen, He Zhao, Zhen Zhang, Huan Liu   +4 more
doaj   +1 more source

Triple condensate halo from water droplets impacting on cold surfaces

, 2018
Understanding the dynamics in the deposition of water droplets onto solid surfaces is of importance from both fundamental and practical viewpoints. While the deposition of a water droplet onto a heated surface is extensively studied, the characteristics ...
Jin, Liwen, New, Tze How, Yang, Chun, Zhang, Hui, Zhao, Yugang, Zhu, Fangqi   +5 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High‐throughput formation of miniaturized cocultures of 2D cell monolayers and 3D cell spheroids using droplet microarray

Droplet, 2023
Most of the biological processes, including cell signaling, cancer invasion, embryogenesis, or neural development, are dependent on and guided by the complex architecture and composition of cellular microenvironments.
Haijun Cui, Tina Tronser, Xianxian Wang, Janine Wesslowski, Gary Davidson, Anna A. Popova, Pavel A. Levkin   +6 more
doaj   +1 more source

Polygonal excitations of spinning and levitating droplets

, 2008
The shape of a weightless spinning liquid droplet is governed by the balance between the surface tension and centrifugal forces. The axisymmetric shape for slow rotation becomes unstable to a non-axisymmetric distortion above a critical angular velocity,
J. Plateau, L. Eaves, N. K. Radyakin, R. J. A. Hill, T. G. Wang   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source