Results 61 to 70 of about 197,231 (268)
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Unified 1/2 scaling laws for droplet impact dynamics: From rigid to flexible thin films
DropletDroplet impact dynamics on solid surfaces, which are ubiquitously present in aerospace engineering, energy systems, agricultural production, etc., involve complex fluid–structure interactions.
Junming Peng, Xianfu Huang, Quanzi Yuan
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Unveiling nanodroplet impact force on material interfaces
DropletNanodroplet impact on nanoscale material interfaces is widely involved in nanoscience and nanotechnology, affecting the technical reliability through complicated liquid‒solid interaction force, that is, the droplet impact force.
Zhifeng Hu +5 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
New insights into suspended drops: When soft matter meets acoustic levitation
DropletAcoustic levitation has developed into a popular but elegant tool for the study of drops as well as soft matter due to its exceptional levitation capabilities to a variety of liquid samples.
Hongyue Chen, Zhenyu Hong, Duyang Zang
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
DropletThe unique properties to combine the dual merits of both liquids and metals together make the gallium‐based liquid metal (LM) droplets a class of unconventional substitute which possess great potential for a group of newly emerging areas, such as ...
Xi Zhao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Chemically robust superhydrophobic surfaces with a self‐replenishing nanoscale liquid coating
DropletDue to poor chemical robustness, superhydrophobic surfaces become susceptible to failure, especially in a highly oxidative environment. To ensure the long‐term efficacy of these surfaces, a more stable and environmentally friendly coating is required to ...
Xiaoteng Zhou +12 more
doaj +1 more source