Results 111 to 120 of about 322,402 (318)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Single‐Target Pairing System (StarPair) for Large‐Scale Interrogation of Cell–Cell Interactions

Advanced Science
Coordination of cell populations through intercellular interactions is essential to the formation and function of living organisms. However, technologies enabling systematic dissection of cell–cell communications or manipulation of cell–cell interactions
Tianjiao Mao, Lang Nan, Miao Xu, Kehao Zeng, Yuchao Wang, Ziyu Han, Ho Cheung Shum   +6 more
doaj   +1 more source

Single droplet experimentation on spray drying:evaporation of sessile droplets deposited on a flat surface

, 2010
: Individually dispensed droplets were dried on a flat surface to mimic the drying of single droplets during spray drying. A robust dispensing process is presented that generates small droplets (dp>150 µm).
Fox, M.B., Perdana, J.A., Schutyser, M.A.I., Boom, R.M.   +3 more
core  

Inertial migration of deformable droplets in a microchannel

, 2014
The microfluidic inertial effect is an effective way of focusing and sorting droplets suspended in a carrier fluid in microchannels. To understand the flow dynamics of microscale droplet migration, we conduct numerical simulations on the droplet motion ...
Xue CD(薛春东), Sun JS(孙佳姝), Beijing Engineering Research Center for BioNanotechnology and Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China, Sun JS(孙佳姝), Hu GQ(胡国庆), Chen XD(陈晓东), Zhang L, Hu GQ(胡国庆), State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics,Chinese Academy of Sciences, Beijing 100190, China, Jiang XY   +7 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fluid Dynamics of Interacting Rotor Wake with a Water Surface

Drones
Rotor-type cross-media vehicles always induce considerably complex mixed air–water flows when approaching the water surface, resulting in relative thrust loss and structural damage on rotor.
Xing-Zhi Bai, Zhe Zhang, Wen-Hua Wu, Xiao Wang, Qi Zhan, Dai-Xian Zhang, Lei Yu   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Fundamental studies of combustion of droplet and vapour mixtures [PDF]

, 2010
There are few experimental data of a fundamental nature that clearly demonstrate the similarities and differences in burning rates between single phase and two phase combustion, either in laminar or turbulent conditions. Such data are essential towards a
Saat, Aminuddin
core  

A millifluidic calorimeter with InfraRed thermography for the measurement of chemical reaction enthalpy and kinetics [PDF]

, 2008
The aim of this work is to present an infrared calorimeter for the measurement of the kinetics and the enthalpy of high exothermic chemical reactions. The main idea is to use a millifluidic chip where the channel acts as a chemical reactor.
PRADERE, Christophe, TOUTAIN, Jean, HANY, Cindy, BATSALE, Jean-Christophe   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source