Results 41 to 50 of about 710,573 (349)

Exploring Autophagy in Drosophila [PDF]

open access: yesCells, 2017
Autophagy is a catabolic process in eukaryotic cells promoting bulk or selective degradation of cellular components within lysosomes. In recent decades, several model systems were utilized to dissect the molecular machinery of autophagy and to identify the impact of this cellular “self-eating” process on various physiological and pathological processes.
Caroline Mauvezin   +3 more
openaire   +7 more sources

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs [PDF]

open access: yes, 2010
Background: As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated.
Stathopoulos, Angelike, Tulin, Sarah
core   +4 more sources

qDATA - an R application implementing a practical framework for analyzing quantitative real-time PCR data

open access: yesBioTechniques
Gene expression assays that are based on quantitative real-time PCR (qRT-PCR) method are still very popular, therefore, we developed qDATA, an open-source R-based bioinformatics application that offers a quick and intuitive analysis of raw cycle ...
Adrian Ionascu   +3 more
doaj   +1 more source

Drosophila errantiviruses [PDF]

open access: yesMobile Genetic Elements, 2012
Retroelements with long-terminal repeats (LTRs) inhabit nearly all eukaryotic genomes. During the time of their rich evolutionary history they have developed highly diverse forms, ranging from ordinary retrotransposons to complex pathogenic retroviruses such as HIV-I.
Stefanov, Yury   +2 more
openaire   +2 more sources

Hawaiian Picture‐Winged Drosophila Exhibit Adaptive Population Divergence along a Narrow Climatic Gradient on Hawaii Island [PDF]

open access: yes, 2019
1. Anthropogenic influences on global processes and climatic conditions are increasingly affecting ecosystems throughout the world. 2. Hawaii Island’s native ecosystems are well studied and local long‐term climatic trends well documented, making these ...
Bellinger, M. Renee   +2 more
core   +2 more sources

A novel insertional allele of the CG18135 gene is associated with severe mutant phenotypes in Drosophila melanogaster

open access: yesFrontiers in Genetics
Drosophila melanogaster has been at the forefront of genetic studies and biochemical modeling for over a century. Yet, the functions of many genes are still unknown, mainly because no phenotypic data are available.
Attila Cristian Ratiu   +4 more
doaj   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

open access: yesFEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai   +2 more
wiley   +1 more source

The selectivity and specificity of autophagy in drosophila [PDF]

open access: yes, 2012
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Chou   +27 more
core   +2 more sources

On the Dispersal of Drosophila

open access: yesThe American Naturalist, 1966
Uploaded by Plazi for TaxoDros. We do not have abstracts.
openaire   +4 more sources

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