Results 71 to 80 of about 842,087 (402)

Drosophila as a Genetic Model for Hematopoiesis

Genetics, 2019
In this FlyBook chapter, we present a survey of the current literature on the development of the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of cells that function in innate immunity, tissue integrity, wound healing,
U. Banerjee, Juliet R. Girard, Lauren M. Goins, Carrie M Spratford   +3 more
semanticscholar   +1 more source

Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF

Advanced Science, EarlyView.
MetaTF is a new computational framework that uses single‐cell RNA sequencing (scRNA‐seq) data to infer transcription factor activity with the aim to help in deciphering cells identity starting from a heterogeneous population, and apply it to characterize mouse hematopoietic stem cells and breast cancer epithelial cells, thus identifying a novel subset ...
Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li, Xiaobo Li, Dong Wang   +15 more
wiley   +1 more source

Genome of Drosophila suzukii, the spotted wing drosophila. [PDF]

, 2013
Drosophila suzukii Matsumura (spotted wing drosophila) has recently become a serious pest of a wide variety of fruit crops in the United States as well as in Europe, leading to substantial yearly crop losses.
Begun, David J, Chiu, Joanna C, Cridland, Julie M, Hamby, Kelly A, Hamm, Christopher A, Jiang, Xuanting, Kwok, Rosanna S, Lee, Ernest K, Saelao, Perot, Walton, Vaughn M, Zalom, Frank G, Zhang, Guojie, Zhao, Li   +12 more
core   +2 more sources

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

Advanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae, Myung‐kyu Choi, Soungyub Ahn, Gwanho Ko, Daniel T. Choe, Hyunsoo Yim, Ken C. Nguyen, Jinseop S. Kim, David H. Hall, Junho Lee   +9 more
wiley   +1 more source

siRNA screen identifies QPCT as a druggable target for Huntington's disease. [PDF]

, 2015
Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT).
Andreini, Matteo, Caradonna, Nicola P., Caramelli, Chiara, Caricasole, Andrea, Dami, Teresa Ed, Diamanti, Daniela, Fleming, Angeleen, Gonzalez-Couto, Eduardo, Hannus, Michael, Heitz, Freddy, Imarisio, Sara, Jimenez-Sanchez, Maria, Lam, Wun, Lazzeroni, Giulia, Marconi, Guido, Massai, Luisa, Menzies, Fiona, Nencini, Arianna, O?Kane, Cahir J., Pollio, Giuseppe, Porcari, Valentina, Rubinsztein, David C., S?nnichsen, Birte, Sardone, Gian Luca, Satagopam, Venkata P., Scali, Carla, Schneider, Reinhard, Tarditi, Alessia, Xu, Catherine   +28 more
core   +5 more sources

Drosophila by the dozen [PDF]

Genome Biology, 2007
A report of the 48th Annual Drosophila Research Conference, Philadelphia, USA, 7-11 March 2007.
Celniker, Susan E., Hoskins, Roger A.
openaire   +4 more sources

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila

Communications Biology, 2021
Lee and colleagues report the effect of a high-sucrose diet on Drosophila locomotor activity via DTk-TkR86C neuropeptide signalling. This signalling pattern appears to involve a circadian element, with pacemaker neuron involvement having a possible time ...
Sang Hyuk Lee, Eunjoo Cho, Sung-Eun Yoon, Youngjoon Kim, Eun Young Kim   +4 more
doaj   +1 more source

Acorns as Breeding Sites for \u3ci\u3eChymomyza Amoena\u3c/i\u3e (Loew) (Diptera: Drosophilidae) in Virginia and Michigan [PDF]

, 2017
Chymomyza amoena is the only chymomyzid fly emerging from white oak acorns in Virginia. An average of 2-3 adult flies emerged from a single acorn in July while emergence declined to 0.4 adults/acorns in September.
Band, Henretta Trent
core   +2 more sources