Results 171 to 180 of about 428,367 (405)
Enhancer‐dependent gene regulation in space, time, and malignancies
International Journal of Cancer, EarlyView.Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum +2 more
wiley +1 more source
Conformity in mate choice, the overlooked social component of animal and human culture
Biological Reviews, Volume 98, Issue 1, Page 132-149, February 2023., 2023 ABSTRACT Although conformity as a major driver for human cultural evolution is a well‐accepted and intensely studied phenomenon, its importance for non‐human animal culture has been largely overlooked until recently. This limited for decades the possibility of studying the roots of human culture.
Sabine Nöbel +5 more
wiley +1 more source
Female Drosophila melanogaster respond to song-amplitude modulations
Biology Open, 2018 Males in numerous animal species use mating songs to attract females and intimidate competitors. We demonstrate that modulations in song amplitude are behaviourally relevant in the fruit fly Drosophila. We show that Drosophila melanogaster females prefer
Birgit Brüggemeier +3 more
doaj +1 more source
Origin and Spread of de Novo Genes in Drosophila melanogaster Populations
Science, 2014 Novel genes derived from ancestral noncoding sequences are polymorphic among fruit fly strains. Comparative genomic analyses have revealed that genes may arise from ancestrally nongenic sequence.
Li Zhao +3 more
semanticscholar +1 more source
SERCA is critical to control the Bowditch effect in the heart [PDF]
, 2018 The Bowditch effect or staircase phenomenon is the increment or reduction of contractile force when heart rate increases, defined as either a positive or negative staircase.
Balcazar, Dario Emmanuel +6 more
core +2 more sources
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Analytical Chemistry, 2014 The methylation of cytosine to 5-methylcytosine (5-meC) is an important epigenetic DNA modification in many bacteria, plants, and mammals, but its relevance for important model organisms, including Caenorhabditis elegans and Drosophila melanogaster, is ...
F. Capuano +4 more
semanticscholar +1 more source
DrosOCB: a high resolution map of conserved non coding sequences in Drosophila [PDF]
arXiv, 2007 Comparative genomics methods are widely used to aid the functional annotation of non coding DNA regions. However, aligning non coding sequences requires new algorithms and strategies, in order to take into account extensive rearrangements and turnover during evolution.
arxiv
Front. Gene., 2012 This paper describes a new program SnpSift for filtering differential DNA sequence variants between two or more experimental genomes after genotoxic chemical exposure.
Pablo Cingolani +6 more
semanticscholar +1 more source
Population genomics on the fly: recent advances in Drosophila [PDF]
arXiv, 2018 Drosophila melanogaster, a small dipteran of African origin, represents one of the best-studied model organisms. Early work in this system has uniquely shed light on the basic principles of genetics and resulted in a versatile collection of genetic tools that allow to uncover mechanistic links between genotype and phenotype.
arxiv