Results 41 to 50 of about 280,859 (262)

A protein restricted diet induces a stable increased fat storage phenotype in flies

Toxicology Reports, 2023
Background: Scientific evidence has revealed possible confounders in diet induced obesity models of Drosophila melanogaster. High Sugar Diet (HSD) induction of obesity in flies has been associated with fly hyperosmolarity and glucotoxicity, while High ...
Oscar Hilary Asiimwe, John Rubaihayo, Sheu Oluwadare Sulaiman, Lawrence Obado Osuwat, Keneth Iceland Kasozi   +4 more
doaj   +1 more source

Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.

PLoS Genetics, 2012
Feeding behavior is one of the most essential activities in animals, which is tightly regulated by neuroendocrine factors. Drosophila melanogaster short neuropeptide F (sNPF) and the mammalian functional homolog neuropeptide Y (NPY) regulate food intake.
Seung-Hyun Hong, Kyu-Sun Lee, Su-Jin Kwak, Ae-Kyeong Kim, Hua Bai, Min-Su Jung, O-Yu Kwon, Woo-Joo Song, Marc Tatar, Kweon Yu   +9 more
doaj   +1 more source

Mapping an atlas of tissue-specific Drosophila melanogaster metabolomes by high resolution mass spectrometry [PDF]

, 2013
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues.
Chintapalli, Venkateswara R, Dow, Julian A T, Watson, David G, Al Bratty, Mohammed, Korzekwa, Dominika   +4 more
core   +5 more sources

Neuroprotective Effect and Mechanism of Xanthoceras sorbifolium Oil on Drosophila melanogaster with Alzheimer's Disease

Shipin gongye ke-ji
This study aimed to investigate the neuroprotective effect of Xanthoceras sorbifolium oil (XSO) on the Drosophila melanogaster model of Alzheimer's disease (AD) and to explore the underlying mechanism.
Chenyao XIANG, Duoduo REN, Xuejun CHAI, Jiayue WU, Xiaofan LIU, Yuyu ZHAO, Yongkang ZHAO, Xiaoyan ZHU, Shanting ZHAO   +8 more
doaj   +1 more source

Anti-Aging Effect of Agrocybe aegerita Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota

Foods, 2022
Polysaccharides extracted from Agrocybe aegerita (AAPS) have various physiological effects. In this study, we used the naturally aging Drosophila melanogaster and D-galactose-induced aging mice as animal models to study the anti-aging effects of AAPS via
Xiaoyan Liu, Linxiu Wu, Aijun Tong, Hongmin Zhen, Dong Han, Hongyang Yuan, Fannian Li, Chengtao Wang, Guangsen Fan   +8 more
doaj   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Population Genomics of Sub-Saharan Drosophila melanogaster: African Diversity and Non-African Admixture [PDF]

, 2012
Drosophila melanogaster has played a pivotal role in the development of modern population genetics. However, many basic questions regarding the demographic and adaptive history of this species remain unresolved.
Ryuichi P. Sugino (108811), Sugino, Ryuichi P., David J. Begun (108835), Pool, John E., Corbett-Detig, Russell B., Russell B Corbett-Detig, Marc W Crepeau, Russell B. Corbett-Detig (108808), Pablo Duchen, Charis M Cardeno, Perot Saelao (108831), Cardeno, Charis M, Charles H. Langley (108839), Ryuichi P Sugino, Perot Saelao, Charles H Langley, Emerson, JJ, David J Begun, J J Emerson, Saelao, Perot, Begun, David J, John E. Pool (108804), Charis M. Cardeno (108818), Stevens, Kristian A., Kristian A. Stevens (108814), Marc W. Crepeau (108821), Kristian A Stevens, Pablo Duchen (108824), Langley, Charles H, Begun, David J., Corbett-Detig, Russell B, Emerson, J. J., Sugino, Ryuichi P, Pool, John E, J. J. Emerson (108827), Crepeau, Marc W, Duchén, Pablo, Crepeau, Marc W., Cardeno, Charis M., John E Pool, Langley, Charles H., Stevens, Kristian A   +41 more
core   +1 more source

Rapid Evolution of Autosomal Binding Sites of the Dosage Compensation Complex in Drosophila melanogaster and Its Association With Transcription Divergence

Frontiers in Genetics, 2021
How pleiotropy influences evolution of protein sequence remains unclear. The male-specific lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation of the X chromosome in males.
Aimei Dai, Yushuai Wang, Anthony Greenberg, Zhongqi Liufu, Tian Tang   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Trypanosomatids are common and diverse parasites of Drosophila [PDF]

, 2011
Drosophila melanogaster is an important model system of immunity and parasite resistance, yet most studies use parasites that do not naturally infect this organism.
Wilfert, L., L. WILFERT, F. BAYER, Jiggins, F. M., A. G. A. FERREIRA, B. LONGDON, Ferreira, A. G. A., Longdon, B., Bayer, F., F. M. JIGGINS   +9 more
core   +1 more source