Results 71 to 80 of about 301,416 (332)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

Sperm death and dumping in Drosophila [PDF]

, 2004
Mating with more than one male is the norm for females of many species. In addition to generating competition between the ejaculates of different males, multiple mating may allow females to bias sperm use.
A Civetta, A Civetta, A Cordoba-Aguilar, AG Clark, AS Gilchrist, AS Gilchrist, B Jenzer, BI Arthur, CSP Price, D Scott, FM Hunter, GA Parker, GJ Lefevre, GT Miller, H Alonzo-Pimentel, HDM Moore, JK DeVries, L Xue, LG Harshman, LW Simmons, LW Simmons, M Otronen, MH Gromko, MH Gromko, MR Wheeler, S Pitnick, T Pizzari, TR Birkhead, WB Heed, WG Eberhard   +29 more
core   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

The behavioral repertoire of Drosophila melanogaster in the presence of two predator species that differ in hunting mode.

PLoS ONE, 2019
The fruit fly, Drosophila melanogaster, has proven to be an excellent model organism for genetic, genomic and neurobiological studies. However, relatively little is known about the natural history of D. melanogaster.
Abhijna Parigi, Cody Porter, Megan Cermak, William R Pitchers, Ian Dworkin   +4 more
doaj   +1 more source

Mancozeb impairs mitochondrial and bioenergetic activity in Drosophila melanogaster [PDF]

, 2021
Miriane Acosta Saraiva, Nélson Rodrigues de Carvalho, Illana Kemmerich Martins, Giulianna Echeverria Macedo, Nathane Rosa Rodrigues, Patrícia de Brum Vieira, Marina Prigol, Karen Kich Gomes, Cynthia Camila Ziech, Jeferson Luís Franco, Thaís Posser   +10 more
openalex   +1 more source

The essential roles of metal ions in insect homeostasis and physiology [PDF]

, 2017
Metal ions play distinct roles in living organisms, including insects. Some, like sodium and potassium, are central players in osmoregulation and ‘blood and guts’ transport physiology, and have been implicated in cold adaptation.
Dow, Julian A.T.
core   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Modulatory effect of Picralima Nitida on oxidative stress: Cobalt, thiol, total protein in Drosophila melanogaster exposed to lead

Sokoto Journal of Medical Laboratory Science, 2023
Drosophila melanogaster, commonly known as fruit fly, vinegar fly, is a small model organism used in the study of various disciplines. D. biochemical, neurological and physiological sim ilarities with human beings and has about 75% functional homologs of
Osunbor, J.O. Osakue, J.E.
doaj  

Drosophila melanogaster: a fruitful model for oncohistones

Fly, 2021
Drosophila melanogaster has proven to be a powerful genetic model to study human disease. Approximately 75% of human disease-associated genes have homologs in the fruit fly and regulatory pathways are highly conserved in Drosophila compared to humans ...
Amel Chaouch, Paul Lasko
doaj   +1 more source