Results 121 to 130 of about 5,995,584 (403)

PRC1‐Mediated H2Aub Loop Formation and Function in Arabidopsis

Advanced Science, EarlyView.
In the Arabidopsis genome, H2Aub and H3K27me3 marks do not always co‐localize, and some regions are marked exclusively by H2Aub. By using Capture‐Hi‐C, it is found that H2Aub loops are preferentially established between two H2Aub enriched regions.
Lingxiao Luo, Minqi Yang, Zhihan Song, Yali Liu, Suxin Xiao, Dingyue Wang, Myriam Calonje, Hang He, Yue Zhou   +8 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Loss of p24 function in Drosophila melanogaster causes a stress response and increased levels of NF-κB-regulated gene products

BMC Genomics, 2008
Background Secretory and transmembrane proteins traverse the endoplasmic reticulum (ER) and Golgi compartments for final maturation prior to reaching their functional destinations.
Carney Ginger E, Boltz Kara A
doaj   +1 more source

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep

Advanced Science, EarlyView.
The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu, Na Zhang, Zilong Wen, Haitao Wang, Tingting Li, Runlin Ma, Menghua Li, Daxiang Wang, Haiping Shu, Xun Huang, Jianlin Han, Yiqiang Zhao, Qiuyue Liu   +12 more
wiley   +1 more source

Protein Secondary Structure Patterns in Short‐Range Cross‐Link Atlas

Angewandte Chemie, EarlyView.
Short‐range cross‐linking mass spectrometry (XL‐MS) reveals secondary structure‐dependent patterns in proteome‐wide datasets. By integrating XL‐MS data with AlphaFold‐predicted structures, we introduce X‐SPAN, a novel validation metric that assesses data quality and enables pLDDT score benchmarking.
Alice Vetrano, Alessio Di Ianni, Nico Di Fonte, Gianluca Dell'Orletta, Samantha Reale, Isabella Daidone, Claudio Iacobucci   +6 more
wiley   +2 more sources

Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility [PDF]

, 2007
The passive elasticity of the sarcomere in striated muscle is determined by large modular proteins, such as titin in vertebrates. In insects, the function of titin is divided between two shorter proteins, projectin and sallimus (Sls), which are the ...
Ayme-Southgate, Bang, Belinda Bullard, Bullard, Bullard, Bullard, Bullard, Bullard, Champagne, Christoph Burkart, Clayton, De Masi, Dickinson, Djinovic-Carugo, Feng Qiu, Granzier, Hakeda, Hao, Harlow, Henkin, Kevin Leonard, Kolmerer, Kontrogianni-Konstantopoulos, Kreisköther, Kulke, Labeit, Lakey, Lakey, Leake, Lehmann, Liu, Machado, Machado, Morin, Patel, Peckham, Petra Hååg, Rosenfeld, Saide, Shapiro, Siegfried Labeit, Sigrun Brendel, Small, Southgate, Sutter, Tatsumi, Tokayasu, Trinick, Tskhovrebova, van Straaten, Vigoreaux, Vladimir Benes, Young, Zhang   +53 more
core   +1 more source

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Protein kinase C in drosophila

, 1990
Bibliography: p. 209-233.
openaire   +3 more sources

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.

Proceedings of the National Academy of Sciences of the United States of America, 1993
Both decapentaplegic (dpp) protein and 60A protein have been implicated in pattern formation during Drosophila melanogaster embryogenesis. Within the C-terminal domain, dpp and 60A are similar to human bone morphogenetic protein 2 (75% identity) and ...
T. Sampath, K. Rashka, J. Doctor, R. Tucker, F. Hoffmann   +4 more
semanticscholar   +1 more source