Results 131 to 140 of about 219,755 (269)

The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in <i>Drosophila</i>. [PDF]

Front Endocrinol (Lausanne)
Moulin TC, Williams MJ, Schiöth HB.
europepmc   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

The formation and function of intercellular bridges in male germlines. [PDF]

Commun Biol
Cui J, Cheng J, Wu B, He A.
europepmc   +1 more source

Trapped in the web: network architectures spread coevolution and shape adaptation

Oikos, EarlyView.
Adaptation is critical for biodiversity to persist under global change. Within ecological communities, species often face tradeoffs between adapting to shifting abiotic conditions and navigating the complex selective pressures imposed by interaction networks.
Alexandre Fuster‐ Calvo, Cecilia S. Andreazzi, Christine Parent, François Massol, Paulo R. Guimarães Jr, Dominique Gravel   +5 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

<i>Wolbachia</i> uses ankyrin repeats to target specific fly proteins. [PDF]

mBio
Hamilton W, Hardy E, López-Madrigal S, Phelps M, Martin M, Newton I.   +5 more
europepmc   +1 more source

Ankh‐Score Produces Better Sequence Alignments Than AlphaFold3

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein sequence alignment is one of the most fundamental procedures in bioinformatics. Due to its many downstream applications, improvements to this procedure are of great importance. We consider two revolutionary concepts that emerged recently as candidates for improving the state‐of‐the‐art alignment methods: AlphaFold and protein language ...
Julia Malec, Karina Rusen, G. Brian Golding, Lucian Ilie   +3 more
wiley   +1 more source

Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein. [PDF]

PLoS Genet
Borne F, Taverner AM, Andolfatto P.
europepmc   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Chitosan‐protected dsRNA increases efficacy against Helicoverpa armigera without compromising biosafety for pollinators

Pest Management Science, EarlyView.
Chitosan/tripolyphosphate/double‐stranded RNA (dsRNA) nanoparticles enhance RNA interference efficacy of orally delivered dsRNA against Helicoverpa armigera. Nanoparticles reduce the LC50 and do not cause deleterious effects or toxicity on beneficial insects.
Daniel DN Vasquez, Lays A Teixeira, Rangel F Alves, Raire Cavalcante, Leonardo LP Macedo, Carmen SS Pires, Luciano P Silva, Maria CM Silva, Feras M Afifi, Carolina V Morgante, Martin G Edwards, Angharad MR Gatehouse, Maria F Grossi‐de‐Sa   +12 more
wiley   +1 more source