Results 131 to 140 of about 3,212 (218)

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Presynaptic Congenital Myasthenic Syndromes

Muscle &Nerve, EarlyView.
ABSTRACT Presynaptic congenital myasthenic syndromes (CMS) encompass a large number of rare neurologic disorders caused by impaired release of acetylcholine (ACh) from motor nerve terminals. There are two main groups of presynaptic CMS: one in which the amount of ACh in synaptic vesicles (SV) is diminished and another in which the mechanism of synaptic
Ricardo A. Maselli
wiley   +1 more source

Ankh‐Score Produces Better Sequence Alignments Than AlphaFold3

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein sequence alignment is one of the most fundamental procedures in bioinformatics. Due to its many downstream applications, improvements to this procedure are of great importance. We consider two revolutionary concepts that emerged recently as candidates for improving the state‐of‐the‐art alignment methods: AlphaFold and protein language ...
Julia Malec, Karina Rusen, G. Brian Golding, Lucian Ilie   +3 more
wiley   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Commercial permethrin elicits chemoreceptive responses on different Anopheles gambiae sensory appendages

Pest Management Science, EarlyView.
Anopheles gambiae mosquitoes exhibit takeoff responses when presented to commercial permethrin headspace. This product elicits electrophysiological activity in the antennae and tarsi. However, only the chemical information acquired from the tarsi plays a major role in the observed behavioral response.
Sassan S Kambou, Adeline Valente, Philip Agnew, Anna Cohuet, David Carrasco   +4 more
wiley   +1 more source

Drosophila Genetics and the Functions of Synaptic Proteins

Cold Spring Harbor Symposia on Quantitative Biology, 1995
K, Parfitt, N, Reist, J, Li, R, Burgess, D, Deitcher, A, DiAntonio, T L, Schwarz   +6 more
openaire   +2 more sources

Identification of broadly expressed nervous system‐related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys

Pest Management Science, EarlyView.
Broadly expressed genes outperformed brain‐enriched neural targets as RNAi candidates in Halyomorpha halys. Microinjection of dsRNA targeting alpha‐soluble NSF attachment protein (Asnap) or Ras opposite protein (Rop) caused strong feeding suppression and near‐complete mortality, identifying them as promising targets for future oral or spray‐based RNAi ...
Nirakar Panda, Aline Koch, Venkata Partha Sarathi Amineni   +2 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source