Results 61 to 70 of about 387,028 (358)

Heat shock proteins and Drosophila aging [PDF]

Experimental Gerontology, 2011
Since their discovery in Drosophila, the heat shock proteins (Hsps) have been shown to regulate both stress resistance and life-span. Aging is characterized by increased oxidative stress and the accumulation of abnormal (malfolded) proteins, and these stresses induce Hsp gene expression through the transcription factor HSF.
openaire   +2 more sources

Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility [PDF]

, 2007
The passive elasticity of the sarcomere in striated muscle is determined by large modular proteins, such as titin in vertebrates. In insects, the function of titin is divided between two shorter proteins, projectin and sallimus (Sls), which are the ...
Ayme-Southgate, Bang, Belinda Bullard, Bullard, Bullard, Bullard, Bullard, Bullard, Champagne, Christoph Burkart, Clayton, De Masi, Dickinson, Djinovic-Carugo, Feng Qiu, Granzier, Hakeda, Hao, Harlow, Henkin, Kevin Leonard, Kolmerer, Kontrogianni-Konstantopoulos, Kreisköther, Kulke, Labeit, Lakey, Lakey, Leake, Lehmann, Liu, Machado, Machado, Morin, Patel, Peckham, Petra Hååg, Rosenfeld, Saide, Shapiro, Siegfried Labeit, Sigrun Brendel, Small, Southgate, Sutter, Tatsumi, Tokayasu, Trinick, Tskhovrebova, van Straaten, Vigoreaux, Vladimir Benes, Young, Zhang   +53 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

In vivo protein trapping in Drosophila [PDF]

Briefings in Functional Genomics and Proteomics, 2003
The deciphering of complete genome sequences has opened a post-genomic proteomics era. While the sequence of many proteins is now known, attention will increasingly focus on the complex interaction networks that regulate their activity, and the analysis of protein distribution in the cell will be crucial to elucidating their function.
openaire   +2 more sources

Trithorax group proteins: switching genes on and keeping them active [PDF]

, 2011
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G., Iovino, N., Martinez, A., Schuettengruber, B.   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. [PDF]

, 2012
The elongation of tissues and organs during embryonic development results from the coordinate polarization of cell behaviors with respect to the elongation axis.
Bilder, David, Gerlach, Gary, Hill, Joseph, Horne-Badovinac, Sally, Menegas, William   +4 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development

G3: Genes, Genomes, Genetics, 2016
Conserved from yeast to humans, the Paf1 complex participates in a number of diverse processes including transcriptional initiation and polyadenylation. This complex typically includes five proteins: Paf1, Rtf1, Cdc73, Leo1, and Ctr9.
Dhananjay Chaturvedi, Mayu Inaba, Shane Scoggin, Michael Buszczak   +3 more
doaj   +1 more source

Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins. [PDF]

PLoS ONE, 2012
BACKGROUND:Cabut (Cbt) is a C(2)H(2)-class zinc finger transcription factor involved in embryonic dorsal closure, epithelial regeneration and other developmental processes in Drosophila melanogaster. Cbt orthologs have been identified in other Drosophila
Yaiza Belacortu, Ron Weiss, Sebastian Kadener, Nuria Paricio   +3 more
doaj   +1 more source