Results 41 to 50 of about 3,212 (218)

Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development

G3: Genes, Genomes, Genetics, 2016
Conserved from yeast to humans, the Paf1 complex participates in a number of diverse processes including transcriptional initiation and polyadenylation. This complex typically includes five proteins: Paf1, Rtf1, Cdc73, Leo1, and Ctr9.
Dhananjay Chaturvedi, Mayu Inaba, Shane Scoggin, Michael Buszczak   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins. [PDF]

PLoS ONE, 2012
BACKGROUND:Cabut (Cbt) is a C(2)H(2)-class zinc finger transcription factor involved in embryonic dorsal closure, epithelial regeneration and other developmental processes in Drosophila melanogaster. Cbt orthologs have been identified in other Drosophila
Yaiza Belacortu, Ron Weiss, Sebastian Kadener, Nuria Paricio   +3 more
doaj   +1 more source

Profiling of RNA-binding Proteins Interacting With Glucagon and Adipokinetic Hormone mRNAs

Journal of Lipid and Atherosclerosis, 2022
Objective Glucagon in mammals and its homolog (adipokinetic hormone [AKH] in Drosophila melanogaster) are peptide hormones which regulate lipid metabolism by breaking down triglycerides. Although regulatory mechanisms of glucagon and AKH expression have
Seungbeom Ko, Eunbyul Yeom, Yoo Lim Chun, Hyejin Mun, Marina Howard-McGuire, Nathan T. Millison, Junyang Jung, Kwang-Pyo Lee, Changhan Lee, Kyu-Sun Lee, Joe R. Delaney, Je-Hyun Yoon   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In-silico definition of the Drosophila melanogaster matrisome

Matrix Biology Plus, 2019
The extracellular matrix (ECM) is an assembly of hundreds of proteins that structurally supports the cells it surrounds and biochemically regulates their functions.
Martin N. Davis, Sally Horne-Badovinac, Alexandra Naba   +2 more
doaj   +1 more source

Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila [PDF]

Open Biology, 2018
The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present changes in gene expression reflecting altered chromatin conformation.
Natacha Raich, Souhir Mahmoudi, Doruk Emre, Roger E. Karess   +3 more
doaj   +1 more source

Heat shock proteins and Drosophila aging [PDF]

Experimental Gerontology, 2011
Since their discovery in Drosophila, the heat shock proteins (Hsps) have been shown to regulate both stress resistance and life-span. Aging is characterized by increased oxidative stress and the accumulation of abnormal (malfolded) proteins, and these stresses induce Hsp gene expression through the transcription factor HSF.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source