Results 31 to 40 of about 3,212 (218)

Identification and Investigation of Postsynaptic Density Homologs

Bioinformatics and Biology Insights, 2008
AMPA receptors are responsible for fast excitatory transmission in the CNS and the trafficking of these receptors has been implicated in LTP and learning and memory. These receptors reside in the postsynaptic density, a network of proteins that links the
Faith L.W. Liebl, David E. Featherstone
doaj   +1 more source

Exploring Strategies for Protein Trapping in Drosophila [PDF]

Genetics, 2007
AbstractThe use of fluorescent protein tags has had a huge impact on cell biological studies in virtually every experimental system. Incorporation of coding sequence for fluorescent proteins such as green fluorescent protein (GFP) into genes at their endogenous chromosomal position is especially useful for generating GFP-fusion proteins that provide ...
Ana T, Quiñones-Coello, Lisa N, Petrella, Kathleen, Ayers, Anthony, Melillo, Stacy, Mazzalupo, Andrew M, Hudson, Shu, Wang, Claudia, Castiblanco, Michael, Buszczak, Roger A, Hoskins, Lynn, Cooley   +10 more
openaire   +2 more sources

Use of Farnesyl Transferase Inhibitors in an Ageing Model in Drosophila

Journal of Developmental Biology, 2023
The presence of farnesylated proteins at the inner nuclear membrane (INM), such as the Lamins or Kugelkern in Drosophila, leads to specific changes in the nuclear morphology and accelerated ageing on the organismal level reminiscent of the Hutchinson ...
Annely Brandt, Roman Petrovsky, Maria Kriebel, Jörg Großhans   +3 more
doaj   +1 more source

BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila

Nature Communications, 2019
The BEN-solo proteins—including Insensitive (Insv), Elba1 and Elba2—function in both transcriptional repression and chromatin insulation. Here, the authors investigate the role of these proteins in Drosophila embryos, finding that ELBA and Insv function ...
Malin Ueberschär, Huazhen Wang, Chun Zhang, Shu Kondo, Tsutomu Aoki, Paul Schedl, Eric C. Lai, Jiayu Wen, Qi Dai   +8 more
doaj   +1 more source

Drosophila's contribution to stem cell research [v1; ref status: indexed, http://f1000r.es/5h7]

F1000Research, 2015
The discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. A recent development in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell ...
Gyanesh Singh
doaj   +1 more source

Drosophila's contribution to stem cell research [version 2; referees: 2 approved]

F1000Research, 2016
The discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. Recent developments in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell ...
Gyanesh Singh
doaj   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source