Results 31 to 40 of about 1,364 (160)

Clinical management of neurogenic orthostatic hypotension

Annals of Movement Disorders, 2019
Neurogenic orthostatic hypotension is a common disorder often seen in elderly patients affected with neurodegenerative disorders and peripheral neuropathies.
Malligurki Raghurama Rukmani, Ravi Yadav, Pramod K Pal, Talakad N Sathyaprabha   +3 more
doaj   +1 more source

Persistent unexplained chest pain and dyspnea in a patient with coronary artery disease: a case report

BMC Cardiovascular Disorders, 2020
Background Neurogenic orthostatic hypotension, a sustained decrease in blood pressure upon standing, is caused by autonomic nervous system failure and characterized by an insufficient increase in heart rate needed to maintain blood pressure upon standing.
Sameh K. Mobarek
doaj   +1 more source

Treatment of Orthostatic Hypotension Due to Autonomic Dysfunction (Neurogenic Orthostatic Hypotension) in a Patient with Cardiovascular Disease and Parkinson's Disease

Cardiology and Therapy, 2019
Introduction The prevalence of neurogenic orthostatic hypotension (nOH) increases with age and is associated with autonomic failure in neurodegenerative diseases (e.g., Parkinson's disease).
Peter A. McCullough
doaj   +1 more source

The effect of ultrasonic irradiation on the morphology of NiO/Co3O4 nanocomposite and its application to the simultaneous electrochemical determination of droxidopa and carbidopa.

Ultrasonics sonochemistry, 2019
Reyhaneh Torkzadeh-Mahani, M. Foroughi, S. Jahani, M. Kazemipour, Hadi Hassani Nadiki   +4 more
semanticscholar   +2 more sources

Enantiomerically Enriched Aziridine‐2‐carboxylates via Copper‐Catalyzed Reductive Kinetic Resolution of 2H‐Azirines

Angewandte Chemie, Volume 137, Issue 26, June 24, 2025.
Kinetic resolution by copper hydride catalyzed reduction of 2H‐azirines secured optically enriched N‐H aziridine‐2‐carboxylates with excellent diastereoselectivity (>20:1) and good enantioselectivity (up to 94% ee). DFT calculations and non‐covalent interaction analysis established the reaction pathway and revealed two key non‐covalent interactions ...
Yinuo Zheng, Elvis Wang Hei Ng, Antonio Rizzo, Pauline Chiu   +3 more
wiley   +2 more sources

Droxidopa for Treatment of Refractory Orthostatic Hypotension in Patients with AL Amyloidosis: A Case Series

Blood, 2021
Background Orthostatic hypotension due to autonomic dysfunction is a well-known complication of light chain (AL) amyloidosis, which can become progressively debilitating and difficult to manage.
Jorge Nicolas Ruiz Lopez, L. Mendelson, T. Joshi, David M. Hughes, M. Kaku, V. Sanchorawala, J. Sloan   +6 more
semanticscholar   +1 more source

Impact of barometric pressure on blood pressure during dialysis: Introducing intradialytic time‐averaged cumulative systolic blood pressure (TACsBP‐inD) as a new metric

Therapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 525-534, June 2025.
Abstract Background Blood pressure is a crucial risk factor for hemodialysis patients, but the specific impact of weather factors, particularly barometric pressure, on blood pressure remains unclear. This study aims to examine the relationship between barometric pressure and blood pressure in hemodialysis patients. Methods We conducted a single‐center,
Kosaku Iwatsubo, Shouichi Fujimoto, Michikazu Nakai   +2 more
wiley   +1 more source

Predictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to treat rare diseases.
Robert Hopefl, Jing Wang, Abhinav Ram Mohan, Wei‐Jhe Sun, Myong‐Jin Kim, Meng Hu, Lanyan Fang   +6 more
wiley   +1 more source

Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches

Journal of Cellular Biochemistry, Volume 126, Issue 8, August 2025.
ABSTRACT Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment ...
Eduarda Moreira Barreto, Gabriel Rodrigues Coutinho Pereira, Isadora de Salles Arêas, Júlia Mendes Fortes, Alessandra da Silva Domingos, Lucio Mendes Cabral, Carlos Rangel Rodrigues, Alessandra Mendonça Teles de Souza, Barbara de Azevedo Abrahim‐Vieira   +8 more
wiley   +1 more source

Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease

Neural Plasticity, 2016
In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu).
Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Liu   +8 more
doaj   +1 more source