Results 51 to 60 of about 1,124 (174)

Ultrasound Assisted Electrochemical Deposition of Polypyrrole - Carbon Nanotube Composite Film: Preparation, Characterization and Application to the Determination of Droxidopa

, 2020
Background: Nowadays, polymeric composites modified with carbonaceous nanomaterials have been popular due to their greater application potentials in many application fields.
Ozdokur, Kemal, V, Kuscu, Ceren, Ertas, Fatma N.   +2 more
core   +1 more source

Predictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to treat rare diseases.
Robert Hopefl, Jing Wang, Abhinav Ram Mohan, Wei‐Jhe Sun, Myong‐Jin Kim, Meng Hu, Lanyan Fang   +6 more
wiley   +1 more source

Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease

Neural Plasticity, 2016
In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu).
Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Liu   +8 more
doaj   +1 more source

Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches

Journal of Cellular Biochemistry, Volume 126, Issue 8, August 2025.
ABSTRACT Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment ...
Eduarda Moreira Barreto, Gabriel Rodrigues Coutinho Pereira, Isadora de Salles Arêas, Júlia Mendes Fortes, Alessandra da Silva Domingos, Lucio Mendes Cabral, Carlos Rangel Rodrigues, Alessandra Mendonça Teles de Souza, Barbara de Azevedo Abrahim‐Vieira   +8 more
wiley   +1 more source

Computational analysis of RNA methyltransferase Rv3366 as a potential drug target for combating drug-resistant Mycobacterium tuberculosis

Frontiers in Molecular Biosciences
Mycobacterium tuberculosis (M.tb) remains a formidable global health threat. The increasing drug resistance among M.tb clinical isolates is exacerbating the current tuberculosis (TB) burden.
Tasmin Nazim, Vipul Kumar, Faraz Ahmed, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain, Durai Sundar, Sonam Grover   +7 more
doaj   +1 more source

Characteristics, Management, and Outcomes of Hospitalized Patients with Orthostatic Hypotension

The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
ABSTRACT Orthostatic hypotension (OH) is a common inpatient condition associated with falls, syncope, and mortality. However, standardized approaches for inpatient management of OH are lacking and may vary across clinical specialties. In this retrospective observational cohort study, we reviewed the electronic medical records of patients admitted to ...
Benjamin A. Wagner, Emily Rose, Adam C. Strauss, Somal Khan, Timothy S. Anderson, Stephen P. Juraschek   +5 more
wiley   +1 more source

Droxidopa for Intravenous Vasopressor Weaning in the Intensive Care Unit: A Descriptive Study

Background/Objectives: Our objective was to describe the safety and efficacy of enteral droxidopa, a norepinephrine prodrug, for intravenous (IV) vasopressor weaning in intensive care unit (ICU) patients.
Amy Kloosterboer, Daniella Veloria, Calvin Diep   +2 more
core   +1 more source

Disautonomia: Uma Condição Esquecida – Parte 1 [PDF]

Arquivos Brasileiros de Cardiologia
Resumo – Pontos Essenciais O termo disautonomia abrange um conjunto de condições clínicas com características e prognósticos distintos. Classificam-se em síndromes reflexas, síndrome postural ortostática taquicardizante (SPOT), síndrome da fadiga crônica,
Eduardo Arrais Rocha, Niraj Mehta, Maria Zildany Pinheiro Távora-Mehta, Camila Ferreira Roncari, Alan Alves de Lima Cidrão, Jorge Elias Neto   +5 more
doaj   +3 more sources

Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin‐Sensitive Magnetic Resonance Imaging and 18F‐Fluorodopa‐Positron Emission Tomography

Movement Disorders, Volume 40, Issue 4, Page 716-726, April 2025.
Abstract Background Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and locus coeruleus (LC).
Paula Trujillo, Kaitlyn R. O'Rourke, Olivia C. Roman, Alexander K. Song, Kilian Hett, Amy Cooper, Bonnie K. Black, Manus J. Donahue, Cyndya A. Shibao, Italo Biaggioni, Daniel O. Claassen   +10 more
wiley   +1 more source

Rhodium-catalyzed asymmetric hydrogenation of tetrasubstituted β-acetoxy-α-enamido esters and efficient synthesis of droxidopa

, 2017
Rhodium-catalyzed asymmetric hydrogenation of challenging tetrasubstituted β-acetoxy-α-enamido esters was developed, giving chiral β-acetoxy-α-amido esters in high yields with excellent enantioselectivities.
Yu-Qing Guan, Xu Deng, Hui Lv, Min Gao, Xumu Zhang   +4 more
core   +1 more source