Results 61 to 70 of about 1,420 (176)
Journal of Cellular Biochemistry, Volume 126, Issue 8, August 2025.ABSTRACT Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment ...
Eduarda Moreira Barreto +8 more
wiley +1 more source
Neural Plasticity, 2016 In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu).
Lei-Fang Cao +8 more
doaj +1 more source
Is Droxidopa Safe and Effective in Reducing Symptoms of Neurogenic Orthostatic Hypotension? [PDF]
, 2017 Objective: The objective of this selective EBM review is to determine whether or not droxidopa is safe and effective in reducing the symptoms of neurogenic orthostatic hypotension.
Longo, Nicholas W
core +1 more source
Efficacy of triple neurotransmitter replacement therapy for patients with progressive supranuclear palsy [PDF]
, 2021 【目的】有効な治療法の確立されていない神経変性疾患である進行性核上性麻痺（ progressive supranuclear palsy: PSP）に対し，障害されているとされる，ドーパミン・ノルアドレナリン・アセチルコリンの３系統の神経伝達物質を同時に補充し，運動機能・認知機能を評価し有効性を明らかにする。 【方法】The National Institute of Neurological Disorders and Stroke and Society for Progressive ...
小澤, 忠嗣, 藤本, 茂
core
Characteristics, Management, and Outcomes of Hospitalized Patients with Orthostatic Hypotension
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.ABSTRACT Orthostatic hypotension (OH) is a common inpatient condition associated with falls, syncope, and mortality. However, standardized approaches for inpatient management of OH are lacking and may vary across clinical specialties. In this retrospective observational cohort study, we reviewed the electronic medical records of patients admitted to ...
Benjamin A. Wagner +5 more
wiley +1 more source
MIBG Predicts Falls in PD [PDF]
, 2021 Background: Falls are associated with poor prognosis in patients with Parkinson's disease (PD). Although several factors related to falls were reported in patients with PD, objective predictors of falls are not identified.
Furukawa, Takahiro +8 more
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Disautonomia: Uma Condição Esquecida – Parte 1 [PDF]
Arquivos Brasileiros de CardiologiaResumo – Pontos Essenciais O termo disautonomia abrange um conjunto de condições clínicas com características e prognósticos distintos. Classificam-se em síndromes reflexas, síndrome postural ortostática taquicardizante (SPOT), síndrome da fadiga crônica,
Eduardo Arrais Rocha +5 more
doaj +3 more sources
Distinguishing Multiple System Atrophy vs Parkinson’s Disease in an African American Woman [PDF]
, 2022 An 87-year-old African American woman with a past medical history of atrial fibrillation on warfarin and peripheral neuropathy with a family history of myasthenia gravis presented to the Emergency Department.
Kane, Mahoua +2 more
core +1 more source
Movement Disorders, Volume 40, Issue 4, Page 716-726, April 2025.Abstract Background Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and locus coeruleus (LC).
Paula Trujillo +10 more
wiley +1 more source
Annals of Neurology, Volume 96, Issue 3, Page 423-440, September 2024.Amyloid neuropathy is caused by deposition of insoluble β‐pleated amyloid sheets in the peripheral nervous system. It is most common in: (1) light‐chain amyloidosis, a clonal non‐proliferative plasma cell disorder in which fragments of immunoglobulin, light or heavy chain, deposit in tissues, and (2) hereditary transthyretin (ATTRv) amyloidosis, a ...
Pitcha Chompoopong +3 more
wiley +1 more source