Results 61 to 70 of about 1,612 (203)
Clinical and Translational Science, Volume 18, Issue 10, October 2025.ABSTRACT Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to treat rare diseases.
Robert Hopefl +6 more
wiley +1 more source
Neural Plasticity, 2016 In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu).
Lei-Fang Cao +8 more
doaj +1 more source
Fibromyalgia pathogenesis provides drug target clues [PDF]
, 2016 Fibromyalgia (FM) has been described as a condition of heightened generalised sensitisation to sensory input presenting as a complex of symptoms dominated by chronic widespread pain characterised by hyperalgesia and allodynia. A range of co-morbidities
Lawson, Kim
core
Distinguishing Multiple System Atrophy vs Parkinson’s Disease in an African American Woman [PDF]
, 2022 An 87-year-old African American woman with a past medical history of atrial fibrillation on warfarin and peripheral neuropathy with a family history of myasthenia gravis presented to the Emergency Department.
Kane, Mahoua +2 more
core +1 more source
Journal of Cellular Biochemistry, Volume 126, Issue 8, August 2025.ABSTRACT Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment ...
Eduarda Moreira Barreto +8 more
wiley +1 more source
Disautonomia: Uma Condição Esquecida – Parte 1 [PDF]
Arquivos Brasileiros de CardiologiaResumo – Pontos Essenciais O termo disautonomia abrange um conjunto de condições clínicas com características e prognósticos distintos. Classificam-se em síndromes reflexas, síndrome postural ortostática taquicardizante (SPOT), síndrome da fadiga crônica,
Eduardo Arrais Rocha +5 more
doaj +3 more sources
Is Droxidopa Safe and Effective in Reducing Symptoms of Neurogenic Orthostatic Hypotension? [PDF]
, 2017 Objective: The objective of this selective EBM review is to determine whether or not droxidopa is safe and effective in reducing the symptoms of neurogenic orthostatic hypotension.
Longo, Nicholas W
core +1 more source
MIBG Predicts Falls in PD [PDF]
, 2021 Background: Falls are associated with poor prognosis in patients with Parkinson's disease (PD). Although several factors related to falls were reported in patients with PD, objective predictors of falls are not identified.
Furukawa, Takahiro +8 more
core
Movement Disorders, Volume 40, Issue 4, Page 716-726, April 2025.Abstract Background Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and locus coeruleus (LC).
Paula Trujillo +10 more
wiley +1 more source
Neurogenic orthostatic hypotension – management update and role of droxidopa
Therapeutics and Clinical Risk Management, 2015 Joy Vijayan,1 Vijay K Sharma1,21Department of Medicine, Division of Neurology, National University Health System, 2Yong Loo Lin School of Medicine, National University of Singapore, SingaporeAbstract: Orthostatic hypotension (OH) is defined as a ...
Vijayan J, Sharma VK
doaj