Results 11 to 20 of about 1,104,169 (198)

Fabrication of Gastro-Floating Famotidine Tablets: Hydroxypropyl Methylcellulose-Based Semisolid Extrusion 3D Printing

Pharmaceutics, 2023
Semisolid extrusion (SSE) three-dimensional (3D) printing uses drug-loaded paste for the printing process, which is capable of constructing intricate 3D structures.
Hyun Seok Yang, Dong Wuk Kim
doaj   +1 more source

Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions

Clinical and Translational Science, 2020
As the research into the organic anion transporting polypeptides (OATPs) continues to grow, it is important to ensure that the data generated are accurate and reproducible.
Savannah J. McFeely, Tasha K. Ritchie, Isabelle Ragueneau‐Majlessi   +2 more
doaj   +1 more source

Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability

Pharmaceutics, 2022
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX).
Bhupendra Raj Giri, Hyun Seok Yang, Im-Sook Song, Han-Gon Choi, Jung Hyun Cho, Dong Wuk Kim   +5 more
doaj   +1 more source

Assessment of potential drug interactions among psychiatric inpatients receiving antipsychotic therapy of a secondary care hospital, United Arab Emirates

Journal of Advanced Pharmaceutical Technology & Research, 2021
The majority of the antipsychotic drugs are also known to interact with other co-administered drugs. Drug–drug interaction (DDI) reports among patients receiving antipsychotic medications are common.
Haneen A. R. Aburamadan, Sathvik Belagodu Sridhar, Talaat Matar Tadross   +2 more
doaj   +1 more source

Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Pharmaceutics, 2022
Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na2CO3 as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the ...
Jaehyeok Lee, Chul Haeng Lee, Jong-Geon Lee, So Yeon Jeon, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting

Pharmaceuticals, 2023
Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via multiple intracellular interactions, generating reactive oxygen species and DNA-adducted configurations that induce apoptosis, topoisomerase II inhibition, and histone ...
Jihoon Lee, Min-Koo Choi, Im-Sook Song
doaj   +1 more source

Improving Drug–Drug Interaction Extraction with Gaussian Noise

Pharmaceutics, 2023
Drug–Drug Interactions (DDIs) produce essential and valuable insights for healthcare professionals, since they provide data on the impact of concurrent administration of medications to patients during therapy.
Marco Molina, Cristina Jiménez, Carlos Montenegro   +2 more
doaj   +1 more source

Clinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants

Pharmaceutics, 2022
Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous fundamental pharmacokinetic knowledge of kratom in humans remains lacking.
Rakshit S. Tanna, James T. Nguyen, Deena L. Hadi, Preston K. Manwill, Laura Flores-Bocanegra, Matthew E. Layton, John R. White, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel, Mary F. Paine   +11 more
doaj   +1 more source

Potential Drug - Drug Interactions among Medications Prescribed to Hypertensive Patients [PDF]

Journal of Clinical and Diagnostic Research, 2014
Context: Drug-drug interactions(DDIs) are significant but avoidable causes of iatrogenic morbidity and hospital admission. Aim: To detect potential drug-drug interactions among medications received by hypertensive patients.
Nitin Kothari, Barna Ganguly
doaj   +1 more source

Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

Journal of Hematology & Oncology, 2020
Background Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway.
Young Sun Choi, Hyeonha Jang, Biki Gupta, Ji-Hak Jeong, Yun Ge, Chul Soon Yong, Jong Oh Kim, Jong-Sup Bae, Im-Sook Song, In-San Kim, You Mie Lee   +10 more
doaj   +1 more source