Results 131 to 140 of about 6,006,054 (377)

Bayer AG v. Housey Pharmaceuticals: Protection for Biotechnological Research Tools under Section 271(g) Found Wanting [PDF]

, 2005
[Excerpt] Research tools, a subset of biotechnological inventions protected by process patents, are “tools that scientists use in the laboratory, including cell lines, monoclonal antibodies, reagents, animal models, growth factors, combinatorial ...
Barthalow, Matthew
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Mechanisms and the clinical relevance of complex drug–drug interactions

Clinical Pharmacology: Advances and Applications, 2018
Arthur G Roberts, Morgan E Gibbs Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA Abstract: As a result of an increasing aging population, the number of individuals taking multiple medications simultaneously has grown ...
Roberts AG, Gibbs ME
doaj  

Effect of a probiotic mixture on the biotransformation and bioavailability of deglycosylated ginsenosides

Journal of Functional Foods
We aimed to investigate the effects of a probiotic mixture comprising Lactiplantibacillus plantarum, Bifidobacterium breve, Bifidobacterium animal subsp.
So Yeon Jeon, Jihoon Lee, Ji-Hyeon Jeon, Juyoung Kim, Yeon-Ju Baek, Min-Koo Choi, Soohyun Sung, Jong Won Kim, Sanghyun Lim, Im-Sook Song   +9 more
doaj   +1 more source

Identification of drug-target interaction by a random walk with restart method on an interactome network

BMC Bioinformatics, 2018
Background Identification of drug-target interactions acts as a key role in drug discovery. However, identifying drug-target interactions via in-vitro, in-vivo experiments are very laborious, time-consuming.
Ingoo Lee, Hojung Nam
doaj   +1 more source

Survey of the Cardiovascular Drug Interactions on Geriatrics at Internal Medicine Ward of RSUDZA Banda Aceh [PDF]

, 2015
The increase of elderly population in Indonesia leads to the drug misuse. The physiological change in geriatric become the major reason. It affects the change of drug\u27s pharmacodynamic, pharmacokinetics and the harmful drug interaction among overly
Suardi, H. N. (Hijra), Suryawati, S. (Suryawati)   +1 more
core  

Evaluation of Drug-Drug Interactions Between Hepatitis C Antiviral Agents Ombitasvir, Paritaprevir/Ritonavir, and Dasabuvir and HIV-1 Protease Inhibitors [PDF]

, 2016
Amit Khatri, Sandeep Dutta, Haoyu Wang, Thomas Podsadecki, Roger Trinh, Walid M. Awni, Rajeev Menon   +6 more
openalex   +1 more source

Randomized pharmacokinetic and drug–drug interaction studies of ceftazidime, avibactam, and metronidazole in healthy subjects

Pharmacology Research & Perspectives, 2015
We assessed pharmacokinetic and safety profiles of ceftazidime–avibactam administered ± metronidazole, and whether drug–drug interactions exist between ceftazidime and avibactam, or ceftazidime‐avibactam and metronidazole.
Shampa Das, Jianguo Li, J. Armstrong, M. Learoyd, T. Edeki   +4 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source