Results 111 to 120 of about 2,242,237 (349)

Mechanisms and the clinical relevance of complex drug–drug interactions

Clinical Pharmacology: Advances and Applications, 2018
Arthur G Roberts, Morgan E Gibbs Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA Abstract: As a result of an increasing aging population, the number of individuals taking multiple medications simultaneously has grown ...
Roberts AG, Gibbs ME
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Drug-DNA interaction protocols

European Journal of Histochemistry, 2010
In a paper published by Jurgen Drews on the march 17, 2000 issue of Science a figure reporting molecular targets of drug therapy, classified according to biochemical criteria, showed that only 2% of drugs were directed to DNA.
Stefano Govoni
doaj   +1 more source

Bayer AG v. Housey Pharmaceuticals: Protection for Biotechnological Research Tools under Section 271(g) Found Wanting [PDF]

, 2005
[Excerpt] Research tools, a subset of biotechnological inventions protected by process patents, are “tools that scientists use in the laboratory, including cell lines, monoclonal antibodies, reagents, animal models, growth factors, combinatorial ...
Barthalow, Matthew
core   +1 more source

Automated Identification of Drug-Drug Interactions in Pediatric Congestive Heart Failure Patients [PDF]

, 2017
Daniel Miller
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effect of a probiotic mixture on the biotransformation and bioavailability of deglycosylated ginsenosides

Journal of Functional Foods
We aimed to investigate the effects of a probiotic mixture comprising Lactiplantibacillus plantarum, Bifidobacterium breve, Bifidobacterium animal subsp.
So Yeon Jeon, Jihoon Lee, Ji-Hyeon Jeon, Juyoung Kim, Yeon-Ju Baek, Min-Koo Choi, Soohyun Sung, Jong Won Kim, Sanghyun Lim, Im-Sook Song   +9 more
doaj   +1 more source

Identification of drug-target interaction by a random walk with restart method on an interactome network

BMC Bioinformatics, 2018
Background Identification of drug-target interactions acts as a key role in drug discovery. However, identifying drug-target interactions via in-vitro, in-vivo experiments are very laborious, time-consuming.
Ingoo Lee, Hojung Nam
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analisis Potensi Interaksi Obat Antidiabetik Oral Pada Pasien Di Instalasi Rawat Jalan Askes Rumah Sakit Dokter Soedarso Pontianak Periode Januari- Maret 2013 [PDF]

, 2013
Drug interaction is one of eight drug-related problems categories that may affectpatient clinical outcome. Increasing complexity of the drugs used in current treatment andthe likelihood of polypharmacy practices, make possible the incident of drug ...
Utami, M. G. (Mega)
core