Results 101 to 110 of about 6,291,138 (303)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Ana Liffey Drug Project annual report 1993
, 1994 I note that the Project commenced in 1982 and since that time the range and level of services has been developed significantly. The Project was established at a time when the need for services for people with HIV/AIDS had not become apparent and it ...
Ana Liffey Drug Project
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Victorian Drug Household Survey, 1993
, 2019 The Victorian Drug Household Survey (VDHS) was conducted as an extension to the fourth National Campaign Against Drugs and Alcohol (NCADA) National Drug Household Survey (NDHS).
Harrison, Stanford
core +1 more source
Drug–drug interactions with imatinib
Medicine, 2016 Many patients treated with imatinib, used in cancer treatment, are using several other drugs that could interact with imatinib. Our aim was to study all the drug-drug interactions (DDIs) observed in patients treated with imatinib.We performed 2 observational studies, between the 1st January 2012 and the 31st August 2015 in the Midi-Pyrénées area (South
Récoché, Isabelle +7 more
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
, 2015 This survey attracted more than 100,000 on line responses from individuals around the world about their drug use. The study looked at prevalence, price, purity, value for money and the proportion of people seeking medical treatment.
Global Drug Survey
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An ontology for drug-drug interactions
, 2015 Drug-drug interactions form a significant risk group for adverse effects associ-ated with pharmaceutical treatment. These interactions are often reported in the literature, however, they are sparsely represented in machine-readable re-sources, such as online databases, thesauri or ontologies.
María Herrero-Zazo +5 more
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Drug-related and drug-misuse deaths 2009-2019.
, 2021 There were 191 drug-related deaths registered in Northern Ireland in 2019. Almost half (45.5%) of these deaths were of men aged 25-44. These are some of the findings of the statistics published today by the Northern Ireland Statistics and Research Agency
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