LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters [PDF]
, 2019 OBJECTIVES: The secondary use of medical data contained in electronic medical records, such as hospital discharge letters, is a valuable resource for the improvement of clinical care (e.g. in terms of medication safety) or for research purposes. However,
Demuth, Ilja +4 more
core +1 more source
Identifikasi Drug Related Problems (DRPs) Potensial Pada Pasien Gagal Jantung Kongestif di Instalasi Rawat Inap RSU PKU Muhammadiyah Delanggu Tahun 2016 [PDF]
, 2018 Congestive heart failure is characterized by a reduced ability of the heart pump due to changes in the structure and function of the heart. DRPs increase the risk of mortality and morbidity in patients with congestive heart failure.
, Puji Asmini, M.Sc., Apt +1 more
core
Position-aware deep multi-task learning for drug–drug interaction extraction [PDF]
, 2018 Objective A drug–drug interaction (DDI) is a situation in which a drug affects the activity of another drug synergistically or antagonistically when being administered together.
Airola +31 more
core +1 more source
Drug-Drug Interaction Pattern Recognition [PDF]
Drugs in R & D, 2010 Drug-drug interaction (DDI) is an important aspect of drug development, especially for safety. When a drug is used concomitantly with other drug(s), one of the major concerns is the change of exposures, including the rate and extent of drug absorption, distribution, metabolism and elimination.
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
DDIGIP: predicting drug-drug interactions based on Gaussian interaction profile kernels
BMC Bioinformatics, 2019 Background A drug-drug interaction (DDI) is defined as a drug effect modified by another drug, which is very common in treating complex diseases such as cancer.
Cheng Yan +4 more
doaj +1 more source
Drugs and violence in Colombia: a VECM analysis [PDF]
, 2009 It has been widely argued that the production of illegal drugs, particularly cocaine, has financed guerrilla activity in Colombia. This paper uses quarterly time-series data for Colombia 1994-2005 to examine the interaction between legal agricultural ...
Gonzalez, T., Smith, Ron P.
core
A simple molecular modeling method for the characterization of polymeric drug carriers [PDF]
, 2013 A simple molecular modeling method for the characterization of polymeric drug carriers is presented. Six biodegradable polymers have been investigated as drug carriers using molecular simulations: l-polylactide, d-polylactide, chitosan, polyglycolic acid,
Macháčková, Miroslava +2 more
core +1 more source