Results 71 to 80 of about 2,242,237 (349)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Viruses, 2015 With the goal of recognizing outstanding contributions to the field of virology by early-career investigators, last year Viruses accepted nominations for a 2015 Young Investigator Prize in Virology. The target age was set at 40 and under.
Eric O. Freed
doaj +1 more source
Trends of Analytical Research on Drug-drug Interaction [PDF]
, 2014 薬物-薬物相互作用は薬物治療において非常に重要な事項である｡薬物はそれ自身で副作用を生じうるが､複数の薬物を併用することで予期しない重篤な有害事象を引き起こすこともある｡この意味で､薬物-薬物相互作用に関する分析化学的な研究が非常に重要であり､薬物治療の手助けとなる｡本総説では､薬物-薬物相互作用の分析化学的研究の最近の動向について､特に微小透析技術に基づいた方法について記述する｡Drug-drug interaction is very important matter for the ...
Kenichiro NAKASHIMA +7 more
core +1 more source
Outcome-based pricing for new pharmaceuticals via rebates [PDF]
, 2020 The price of new brand-name prescription drugs has been rising fast in the United States. For example, the Amgen cholesterol drug Repatha had an initial list price of $14,523 per year.
Adida, E
core
The Price of Progress: Funding and Financing Alzheimer\u27s Disease Drug Development [PDF]
, 2018 Introduction Advancing research and treatment for Alzheimer\u27s disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding ...
Cummings, Jeffrey +2 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Customizable Self-Microemulsifying Rectal Suppositories by Semisolid Extrusion 3D Printing
PharmaceuticsObjectives: This study aims to create an innovative self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen (IBU) using semisolid extrusion (SSE) three-dimensional (3D) printing technology.
Hye Jin Park, Dong Wuk Kim
doaj +1 more source
Assessment of extracts from red yeast rice for herb-drug interaction by in-vitro and in-vivo assays [PDF]
, 2012 Red yeast rice (RYR) is made by fermenting the yeast Monascus purpureus over rice. It is a source of natural red food colorants, a food garnish and a traditional medication.
Fung, W.T. +4 more
core +2 more sources
Informatics confronts drug–drug interactions [PDF]
Trends in Pharmacological Sciences, 2013 Drug-drug interactions (DDIs) are an emerging threat to public health. Recent estimates indicate that DDIs cause nearly 74000 emergency room visits and 195000 hospitalizations each year in the USA. Current approaches to DDI discovery, which include Phase IV clinical trials and post-marketing surveillance, are insufficient for detecting many DDIs and do
Bethany, Percha, Russ B, Altman
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source