Results 61 to 70 of about 6,006,054 (377)

Drug–Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies

European journal of drug metabolism and pharmacokinetics, 2019
Darolutamide is a novel androgen receptor (AR) antagonist approved for the treatment of nonmetastatic castration-resistant prostate cancer (nmCRPC).
C. Zurth, M. Koskinen, R. Fricke, O. Prien, T. Korjamo, K. Graudenz, K. Denner, Michaela Bairlein, Clemens J von Bühler, G. Wilkinson, H. Gieschen   +10 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Drug-Drug Interaction Extraction via Convolutional Neural Networks

Comput. Math. Methods Medicine, 2016
Drug-drug interaction (DDI) extraction as a typical relation extraction task in natural language processing (NLP) has always attracted great attention. Most state-of-the-art DDI extraction systems are based on support vector machines (SVM) with a large ...
Shengyu Liu, Buzhou Tang, Qingcai Chen, Xiaolong Wang   +3 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Chemically cross-linked poly(acrylic-co-vinylsulfonic) acid hydrogel for the delivery of isosorbide mononitrate. [PDF]

, 2013
We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels.
Ansari, Mahvash, Hussain, Talib, Khan, Ikram Ullah, Ranjha, Nazar Muhammad, Shahzad, Yasser   +4 more
core   +2 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Customizable Self-Microemulsifying Rectal Suppositories by Semisolid Extrusion 3D Printing

Pharmaceutics
Objectives: This study aims to create an innovative self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen (IBU) using semisolid extrusion (SSE) three-dimensional (3D) printing technology.
Hye Jin Park, Dong Wuk Kim
doaj   +1 more source

Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning

Pharmaceutics, 2021
An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM ...
Laura Victoria Schulte-Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Nataša Škalko-Basnet, Ann Mari Holsæter   +6 more
doaj   +1 more source

Detecting drug interactions using personal digital assistants in an out-patient clinic [PDF]

, 2017
Background: The installation of drug databases on personal digital assistants (PDAs) allows for rapid detection of adverse drug interactions at the point of care.
Bovier, P.A., Dallenbach, M.Francis, Desmeules, J.   +2 more
core  

Kajian Potensi Interaksi Obat Antihipertensi Pada Pasien Hipertensi Primer Di Instalasi Rawat Jalan RSUD Luwuk Periode Januari – Maret 2016 [PDF]

, 2017
KAJIAN POTENSI INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI PRIMER DI INSTALASI RAWAT JALAN RSUD LUWUK PERIODE JANUARI – MARET 2016 Yesia Stevani Mahamudu1), Gayatri Citraningtyas1), Henki Rotinsulu1)1)Program studi farmasi FMIPA UNSRAT Manado ...
Mahamudu, Y. S. (Yesia)
core   +2 more sources