Results 61 to 70 of about 5,892,906 (287)

Drug–Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies

European journal of drug metabolism and pharmacokinetics, 2019
Darolutamide is a novel androgen receptor (AR) antagonist approved for the treatment of nonmetastatic castration-resistant prostate cancer (nmCRPC).
C. Zurth, M. Koskinen, R. Fricke, O. Prien, T. Korjamo, K. Graudenz, K. Denner, Michaela Bairlein, Clemens J von Bühler, G. Wilkinson, H. Gieschen   +10 more
semanticscholar   +1 more source

Customizable Self-Microemulsifying Rectal Suppositories by Semisolid Extrusion 3D Printing

Pharmaceutics
Objectives: This study aims to create an innovative self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen (IBU) using semisolid extrusion (SSE) three-dimensional (3D) printing technology.
Hye Jin Park, Dong Wuk Kim
doaj   +1 more source

Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning

Pharmaceutics, 2021
An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM ...
Laura Victoria Schulte-Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Nataša Škalko-Basnet, Ann Mari Holsæter   +6 more
doaj   +1 more source

Dolutegravir drug-drug interactions

South African Medical Journal, 2022
Dolutegravir is neither an inducer nor an inhibitor of metabolising enzymes, and it therefore has a low propensity to act as a perpetrator of drug-drug interactions. Clinically significant decreases in dolutegravir exposure occur when it is co-administered with strong inducers (e.g.
Mondleki, E, Maartens, G
openaire   +3 more sources

Detecting drug interactions using personal digital assistants in an out-patient clinic [PDF]

, 2017
Background: The installation of drug databases on personal digital assistants (PDAs) allows for rapid detection of adverse drug interactions at the point of care.
Bovier, P.A., Dallenbach, M.Francis, Desmeules, J.   +2 more
core  

A cell lines derived microfluidic liver model for investigation of hepatotoxicity induced by drug-drug interaction.

Biomicrofluidics, 2019
The poor metabolic ability of cell lines fails to meet the requirements of an in vitro model for drug interaction testing which is crucial for the development or clinical application of drugs.
Jiu Deng, Xiuli Zhang, Zongzheng Chen, Yong Luo, Yao Lu, Tingjiao Liu, Zhengzhi Wu, Yu Jin, Weijie Zhao, B. Lin   +9 more
semanticscholar   +1 more source

Trends of Analytical Research on Drug-drug Interaction [PDF]

, 2014
薬物-薬物相互作用は薬物治療において非常に重要な事項である｡薬物はそれ自身で副作用を生じうるが､複数の薬物を併用することで予期しない重篤な有害事象を引き起こすこともある｡この意味で､薬物-薬物相互作用に関する分析化学的な研究が非常に重要であり､薬物治療の手助けとなる｡本総説では､薬物-薬物相互作用の分析化学的研究の最近の動向について､特に微小透析技術に基づいた方法について記述する｡Drug-drug interaction is very important matter for the ...
Kenichiro NAKASHIMA, Rie IKEDA, Seitaro KAMIYA, Yoshihito OHBA, 中島 憲一郎, 大庭 義史, 池田 理恵, 神谷 誠太郎   +7 more
core   +1 more source

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
core   +1 more source

Systematic Exploration of Synergistic Drug Pairs [PDF]

, 2013
Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs target the products of genes that act in parallel pathways (‘specific synergy’).
Andrews, Brenda J, Baryshnikova, Anastasia, Boone, Charles, Chua, Hon Nian, Cokol, Murat, Costanzo, Michael, Giaever, Guri, Mutlu, Beste, Myers, Chad L, Nergiz, Mehmet E, Nislow, Corey, Roth, Frederick Phillip, Suzuki, Yo, Tasan, Murat, Weinstein, Zohar B   +14 more
core   +1 more source

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021

Clinical and Translational Science, 2023
Kratom is a widely used Asian botanical that has gained popularity in the United States due to a perception that it can treat pain, anxiety, and opioid withdrawal symptoms. The American Kratom Association estimates 10–16 million people use kratom. Kratom‐
Xiaotong Li, Patrick Ndungu, Sanya B. Taneja, Maryann R. Chapin, Susan B. Egbert, Krishi Akenapalli, Mary F. Paine, Sandra L. Kane‐Gill, Richard D. Boyce   +8 more
doaj   +1 more source