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Pharmaceuticals, 2021 Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
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Pharmacodynamic Drug–Drug Interactions [PDF]
Clinical Pharmacology & Therapeutics, 2019 Pharmacodynamic drug–drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused.
Robert M. Straubinger +2 more
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Drug-drug interactions with raltegravir
European Journal of Medical Research, 2009 Objective To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir. Methods A PubMed search was conducted for all published reports up to August 1, 2009 as well as a review of updated European and US ...
Burger David M
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Drug-drug interactions of tacrolimus [PDF]
Hospital Pharmacology, 2015 Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions.
Rančić Nemanja K. +4 more
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DPDDI: a deep predictor for drug-drug interactions
BMC Bioinformatics, 2020 Background The treatment of complex diseases by taking multiple drugs becomes increasingly popular. However, drug-drug interactions (DDIs) may give rise to the risk of unanticipated adverse effects and even unknown toxicity.
Yue-Hua Feng, Shao-Wu Zhang, Jian-Yu Shi
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Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions
Medical Cannabis and Cannabinoids, 2020 Although prescribing information (PI) is often the initial source of information when identifying potential drug-drug interactions, it may only provide a limited number of exemplars or only reference a class of medications without providing any specific ...
Paul T. Kocis, Kent E. Vrana
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Pharmacovigilance of Drug–Drug Interactions with Nirmatrelvir/Ritonavir [PDF]
Infectious Diseases and TherapyIntroduction Nirmatrelvir/ritonavir (NMV/r) is approved in the United States (US) and more than 70 other countries for the treatment of mild to moderate COVID-19 in nonhospitalized adults at high risk for severe disease.
Victoria Hendrick +8 more
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Insights into CYP2B6-mediated drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the ...
William D. Hedrich +2 more
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Renal drug transporters and their significance in drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
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Editorial: Drug-drug interactions in pharmacology
Frontiers in Pharmacology, 2023 Simona Pichini +3 more
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