Results 1 to 10 of about 1,985,312 (191)

Tutorial Drug–Drug Interactions [PDF]

Clinical and Translational Science
Edward M. Sellers
doaj   +4 more sources

Drug-drug interactions with raltegravir

European Journal of Medical Research, 2009
Objective To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir. Methods A PubMed search was conducted for all published reports up to August 1, 2009 as well as a review of updated European and US ...
Burger David M
doaj   +4 more sources

Role of metabolites in drug-drug interactions. [PDF]

Drug Metab Pharmacokinet
Since the publication of the metabolites in safety testing (MIST) guidance by the US FDA in 2009, there has been continuous interest and expansion in research aimed at predicting and characterizing circulating metabolites. Several systematic reviews and original research articles have been published to assess the role of metabolites in drug-drug ...
Isoherranen N.
europepmc   +3 more sources

The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

Pharmaceuticals, 2021
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
doaj   +3 more sources

An ontology for drug-drug interactions [PDF]

, 2014
Proceedings of: The 6th International Workshop on Semantic Web Applications and Tools for Life Sciences (SWAT4LS 2013). Took place 2013, December 11-12, in Edinburgh, UK.
Croset, Samuel, Hastings, Janna, Herrero Zazo, María, Martínez Fernández, Paloma, Segura-Bedmar, Isabel, Steinbeck, Christoph   +5 more
core   +6 more sources

Clinical Evaluation of Drug–Drug Interactions With Aficamten [PDF]

Clinical and Translational Science
Aficamten is a next‐in‐class small molecule cardiac myosin inhibitor that was recently approved by the United States Food and Drug Administration (FDA) for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (oHCM).
Neha Maharao, Donghong Xu, Punag Divanji, Tyrell J. Simkins, Jianlin Li, Camelia Dumitrescu, Priyanka Solanki, Adrienne Griffith, Stephen B. Heitner, Stuart Kupfer, Polina German, Justin D. Lutz   +11 more
doaj   +2 more sources

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial [PDF]

Clinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das, Antoinette (Toni) Ajavon‐Hartmann, Virginia (Ginny) D. Schmith   +2 more
doaj   +2 more sources

Food-Drug Interactions [PDF]

Oman Medical Journal, 2011
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or ...
Arshad Yar Khan, Nousheen Aslam, Rabia Bushra   +2 more
doaj   +2 more sources

Pharmacokinetic Drug–Drug Interactions and Herb–Drug Interactions

Pharmaceutics, 2021
Due to the growing use of herbal supplementation—ease of taking herbal supplements with therapeutics drugs (i [...]
Min-Koo Choi, Im-Sook Song
doaj   +1 more source

Predicting drug-target interactions using drug-drug interactions. [PDF]

PLoS ONE, 2013
Computational methods for predicting drug-target interactions have become important in drug research because they can help to reduce the time, cost, and failure rates for developing new drugs.
Shinhyuk Kim, Daeyong Jin, Hyunju Lee
doaj   +1 more source