Results 31 to 40 of about 1,985,411 (290)
Nature Communications, 2018 SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 ...
Kerstin Schott +14 more
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Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism
Journal of Pharmacological Sciences, 2014 .: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
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The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong +11 more
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Drug–Drug–Gene Interactions in Cardiovascular Medicine
Pharmacogenomics and Personalized Medicine, 2022 Innocent G Asiimwe, Munir Pirmohamed The Wolfson Centre for Personalized Medicine, MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool ...
Asiimwe IG, Pirmohamed M
doaj
Insights into CYP2B6-mediated drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the ...
William D. Hedrich +2 more
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Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]
, 2012 Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu +3 more
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Data-driven prediction of adverse drug reactions induced by drug-drug interactions
BMC Pharmacology and Toxicology, 2017 Background The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-development studies because most of ...
Ruifeng Liu +5 more
doaj +1 more source
Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Medications [PDF]
, 2015 One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and ...
Gandhi, Mona A. +2 more
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Pharmacointeraction Network Models Predict Unknown Drug-Drug Interactions [PDF]
, 2013 Drug-drug interactions (DDIs) can lead to serious and potentially lethal adverse events. In recent years, several drugs have been withdrawn from the market due to interaction-related adverse events (AEs).
Arnold, Alana +3 more
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The study of harmful and beneficial drug interactions in intensive care, Kerman, Iran [PDF]
, 2013 Since multidrug therapy is common in the intensive care unit (ICU), the risk of drug interactions is high. This study aimed to examine the prevalence of drug interactions and risk factors in patients who were admitted to ICUs.
Abdar, M.E. +3 more
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