Results 11 to 20 of about 5,634,975 (396)

The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

Pharmaceuticals, 2021
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
doaj   +2 more sources

Drug-drug interactions with raltegravir

European Journal of Medical Research, 2009
Objective To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir. Methods A PubMed search was conducted for all published reports up to August 1, 2009 as well as a review of updated European and US ...
Burger David M
doaj   +5 more sources

Pharmacodynamic Drug–Drug Interactions [PDF]

Clinical Pharmacology & Therapeutics, 2019
Pharmacodynamic drug–drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused.
Robert M. Straubinger, Donald E. Mager, Jin Niu   +2 more
openaire   +3 more sources

Drug-drug interactions of tacrolimus [PDF]

Hospital Pharmacology, 2015
Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions.
Rančić Nemanja K., Vavić Neven N., Kovačević Aleksandra M., Mikov Momir M., Dragojević-Simić Viktorija M.   +4 more
doaj   +4 more sources

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial [PDF]

Clinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das, Antoinette (Toni) Ajavon‐Hartmann, Virginia (Ginny) D. Schmith   +2 more
doaj   +2 more sources

DPDDI: a deep predictor for drug-drug interactions

BMC Bioinformatics, 2020
Background The treatment of complex diseases by taking multiple drugs becomes increasingly popular. However, drug-drug interactions (DDIs) may give rise to the risk of unanticipated adverse effects and even unknown toxicity.
Yue-Hua Feng, Shao-Wu Zhang, Jian-Yu Shi
doaj   +2 more sources

Insights into CYP2B6-mediated drug–drug interactions

Acta Pharmaceutica Sinica B, 2016
Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the ...
William D. Hedrich, Hazem E. Hassan, Hongbing Wang   +2 more
doaj   +2 more sources

Pharmacovigilance of Drug–Drug Interactions with Nirmatrelvir/Ritonavir [PDF]

Infectious Diseases and Therapy
Introduction Nirmatrelvir/ritonavir (NMV/r) is approved in the United States (US) and more than 70 other countries for the treatment of mild to moderate COVID-19 in nonhospitalized adults at high risk for severe disease.
Victoria Hendrick, Erast Pohorylo, Lubna Merchant, Jackie Gerhart, Iqra Naz Arham, Florin Draica, Romina Quercia, Ayman Ayoub, Reema Mehta   +8 more
doaj   +2 more sources

Renal drug transporters and their significance in drug–drug interactions

Acta Pharmaceutica Sinica B, 2016
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
doaj   +2 more sources

Drug-Drug Interactions and Initial Dosage Optimization of Quetiapine in Patients with Depression: A Real-World Study [PDF]

Drug Design, Development and Therapy
Xiao Chen,1,* Yue Zhang,2,* Di Yin,3,* Ying-Wei Jin,2,4,* Su-Mei He,5 Cun Zhang,6 Dong-Dong Wang2 1School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China; 2School of Pharmacy ...
Chen X, Zhang Y, Yin D, Jin YW, He SM, Zhang C, Wang DD   +6 more
doaj   +2 more sources