Results 11 to 20 of about 4,553,475 (313)
Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding [PDF]
PeerJ, 2018 The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms.
Alexey Smirnov +4 more
doaj +2 more sources
A machine learning framework for predicting drug–drug interactions
Scientific Reports, 2021 Understanding drug–drug interactions is an essential step to reduce the risk of adverse drug events before clinical drug co-prescription. Existing methods, commonly integrating heterogeneous data to increase model performance, often suffer from a high ...
Suyu Mei, Kun Zhang
semanticscholar +1 more source
Pharmaceutics, 2020 In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of
M. Deodhar +6 more
semanticscholar +1 more source
Drug-drug interactions of tacrolimus [PDF]
Hospital Pharmacology, 2015 Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions.
Rančić Nemanja K. +4 more
doaj +1 more source
Drug–Drug Interactions with Direct Oral Anticoagulants
Clinical Pharmacokinetics, 2020 A large body of evidence suggests that not only direct anticoagulant effects but also major bleeding events and stroke prevention depend on plasma concentrations of direct oral anticoagulants (DOACs).
K. Foerster +3 more
semanticscholar +1 more source
Pharmaceutics, 2021 Background: Drug interactions represent a major issue in clinical settings, especially for critically ill patients such as those with cardiovascular disease (CVD) who require cardiothoracic surgery (CTS) and receive a high number of different medications.
Marios Spanakis +4 more
doaj +1 more source
AIMS Molecular Science, 2023 The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases.
Marcus Vinícius Dias-Souza +4 more
doaj +1 more source
The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010
BMC Medicine, 2015 BackgroundThe escalating use of prescribed drugs has increasingly raised concerns about polypharmacy. This study aims to examine changes in rates of polypharmacy and potentially serious drug-drug interactions in a stable geographical population between ...
B. Guthrie +3 more
semanticscholar +1 more source
Detecting drug-drug interactions using artificial neural networks and classic graph similarity measures [PDF]
PLoS ONE, 2019 Drug-drug interactions are preventable causes of medical injuries and often result in doctor and emergency room visits. Computational techniques can be used to predict potential drug-drug interactions.
Guy Shtar, L. Rokach, Bracha Shapira
semanticscholar +1 more source
BMC Cancer, 2022 Introduction During the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products.
Amer A. Koni +8 more
doaj +1 more source