Results 31 to 40 of about 5,522,353 (395)

Prevalence and patterns of higher-order drug interactions in Escherichia coli. [PDF]

, 2018
Interactions and emergent processes are essential for research on complex systems involving many components. Most studies focus solely on pairwise interactions and ignore higher-order interactions among three or more components.
Cruz-Loya, Mauricio, Damoiseaux, Robert, Kang, Tina Manzhu, Savage, Van M, Singh, Nina, Tekin, Elif, White, Cynthia, Yeh, Pamela J   +7 more
core   +2 more sources

Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use

Journal of Clinical Medicine, 2019
Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD has intrinsic pharmacologic effects and associated adverse drug events (ADEs) along with the potential for ...
Joshua D. Brown, A. Winterstein
semanticscholar   +1 more source

Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: Risk factors and impact on indicators of health-related quality of life

Population Medicine, 2022
Introduction While studies have extensively examined the clinical and pharmacokinetic correlates of drug-drug interactions (DDIs) with antiretroviral therapy (ART), less is known about DDIs from the perspective of people living with HIV (PLHIV). Among an
Sejun Park, Yu-Hsiang Hsiao, Fei Yu, Keita Kambara, Brent Allan, Garry Brough, Ta-Fen Hwang, Nathalie Dang, Benjamin Young, Rickesh Patel, Andres Maldonado, Chinyere Okoli   +11 more
doaj   +1 more source

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Drug-drug interactions in the ICU [PDF]

Critical Care, 2009
The present study intended to identify and analyze the significance of drug–drug interaction (DDI) in critically ill patients.
S Ray, Subhash Todi, J Pramanik, M Bhattacharyya   +3 more
openaire   +2 more sources

The impact of CYP2C19 genotype on phenoconversion by concomitant medication

Frontiers in Pharmacology, 2023
Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong, Soukayna Boussallami, Elena Sánchez-López, Martin Giera, Maarten E. Tushuizen, Menno Hoekstra, Lukas J. A. C. Hawinkels, Robert Rissmann, Robert Rissmann, Robert Rissmann, Jesse J. Swen, Martijn L. Manson   +11 more
doaj   +1 more source

Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions

Drug Metabolism And Disposition, 2020
The organic anion transporting polypeptide (OATP)2B1 is localized on the basolateral membrane of hepatocytes and is expressed in enterocytes. Based on its distribution pattern and functional similarity to OATP1B-type transporters, OATP2B1 might have a ...
Mingqing Chen, Shuiying Hu, Yang Li, A. Gibson, Q. Fu, S. Baker, A. Sparreboom   +6 more
semanticscholar   +1 more source

Choosing the safest acute combination therapy during prophylactic treatment. pharmacokinetic and pharmacodynamic considerations [PDF]

, 2015
Drugs used in the treatment of migraine have been recently reported to be highly associated with the occurrence of clinically significant drug-drug interactions (DDIs)
Lionetto, Luana, MARTELLETTI, Paolo
core   +1 more source

Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

Clinical pharmacology and therapy, 2019
Many drug–drug interactions (DDIs) are based on alterations of the plasma concentrations of a victim drug due to another drug causing inhibition and/or induction of the metabolism or transporter‐mediated disposition of the victim drug. In the worst case,
A. Tornio, Anne M. Filppula, M. Niemi, J. Backman   +3 more
semanticscholar   +1 more source

Adverse reactions of amiodarone [PDF]

, 2019
Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo, Ciacciarelli, Marco, Colunga Biancatelli, Ruben Ml, Congedo, Viviana, Iuliano, Luigi, Polidoro, Alessandro   +5 more
core   +1 more source