Results 61 to 70 of about 2,001,669 (363)
FEBS Letters, EarlyView.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Therapeutic Advances in Chronic Disease, 2022 Background: Multiple sclerosis (MS) is the most common immune-mediated demyelinating disease in younger adults. Patients with MS (PwMS) are vulnerable to the presence of potential drug–drug interactions (pDDIs) and potential drug–food interactions (pDFIs)
Jane Louisa Debus +9 more
doaj +1 more source
Interactiveness Field in Human-Object Interactions [PDF]
arXiv, 2022 Human-Object Interaction (HOI) detection plays a core role in activity understanding. Though recent two/one-stage methods have achieved impressive results, as an essential step, discovering interactive human-object pairs remains challenging. Both one/two-stage methods fail to effectively extract interactive pairs instead of generating redundant ...
arxiv
Severe potential drug-drug interactions in older adults with dementia and associated factors [PDF]
, 2016 OBJECTIVE: To identify the main severe potential drug-drug interactions in older adults with dementia and to examine the factors associated with these interactions. METHOD: This was a cross-sectional study.
Bogetti-Salazar, Michele +4 more
core +4 more sources
Drug-Drug Interactions with Antiretroviral Drugs in Pregnant Women Living with HIV : Are They Different from Non-Pregnant Individuals? [PDF]
, 2020 Although the separate effects of drug-drug interactions and pregnancy on antiretroviral drug pharmacokinetics have been widely studied and described, their combined effect is largely unknown.
Bukkems, Vera E. +5 more
core +2 more sources
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Drug-Drug Interaction Pattern Recognition [PDF]
Drugs in R & D, 2010 Drug-drug interaction (DDI) is an important aspect of drug development, especially for safety. When a drug is used concomitantly with other drug(s), one of the major concerns is the change of exposures, including the rate and extent of drug absorption, distribution, metabolism and elimination.
openaire +2 more sources
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
Mobile Base Program for Drug-Drug Interactions (MBPDDIs) [PDF]
Engineering and Technology Journal, 2017 A mobile application program was used in performing a drug-drug interactions (DDIs) for drugs used in Iraq, depending on the drug-drug interactions chart (DDIsC) originated by Ninava Drug Industry (NDI).
N. L. Mohammed +2 more
doaj +1 more source
Drug-Drug Interactions at Organic Cation Transporter 1
Frontiers in Pharmacology, 2021 The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays
Shiwei Zhou +5 more
doaj +1 more source