Results 81 to 90 of about 2,001,669 (363)
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Pharmacointeraction network models predict unknown drug-drug interactions. [PDF]
PLoS ONE, 2013 Drug-drug interactions (DDIs) can lead to serious and potentially lethal adverse events. In recent years, several drugs have been withdrawn from the market due to interaction-related adverse events (AEs).
Aurel Cami +3 more
doaj +1 more source
Herbal - Synthetic Drug Interactions
Magna Medika, 2023 Background: Herbal medicine is currently one of the therapeutic options chosen by the community because it is considered relatively safer and has minimal side effects.
Kintoko Kintoko +7 more
doaj +1 more source
Predicting potential drugs and drug-drug interactions for drug repositioning [PDF]
, 2022 The purpose of drug repositioning is to predict novel treatments for existing drugs. It saves time and reduces cost in drug discovery, especially in preclinical procedures.
Wang, Fei
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions
Medical Cannabis and Cannabinoids, 2020 Although prescribing information (PI) is often the initial source of information when identifying potential drug-drug interactions, it may only provide a limited number of exemplars or only reference a class of medications without providing any specific ...
Paul T. Kocis, Kent E. Vrana
doaj +1 more source
Systematic discovery of drug interaction mechanisms [PDF]
, 2015 Drug combinations are increasingly important in disease treatments, for combating drug resistance, and for elucidating fundamental relationships in cell physiology.
Bollenbach, Mark Tobias +1 more
core +2 more sources
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Provenance for Interactive Visualizations [PDF]
arXiv, 2018 We highlight the connections between data provenance and interactive visualizations. To do so, we first incrementally add interactions to a visualization and show how these interactions are readily expressible in terms of provenance. We then describe how an interactive visualization system that natively supports provenance can be easily extended with ...
arxiv
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source