Results 81 to 90 of about 1,993,579 (343)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A phase I open-label clinical trial to study drug-drug interactions of Dorzagliatin and Sitagliptin in patients with type 2 diabetes and obesity [PDF]

, 2023
Li Chen, Jiayi Zhang, Yu Sun, Yu Zhao, Xiang Liu, Zhiyin Fang, Lingge Feng, Bin He, Quanfei Zou, Gregory J. Tracey   +9 more
openalex   +1 more source

Kajian Interaksi Obat pada Pengobatan Diabetes Melitus (Dm) dengan Hipertensi di Instalasi Rawat Jalan RSUD Undata Periode Maret-juni Tahun 2014 [PDF]

, 2015
One of the chronic complications of diabetes mellitus is a disorder of macrovascular as hypertension so that in it's medicinal treatment required therapy with multiple drugs all at once that can lead to drug interactions.
Faustine, I. (Ingrid), Mukaddas, A. (Alwiyah), Nurlaelah, I. (Ida)   +2 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Antimicrobial and Anti-Inflammatory Potentials of Silver Tungstate Nanoparticles, Cytotoxicity and Interference on the Activity of Antimicrobial Drugs

Drugs and Drug Candidates
Background: Bacterial resistance to antimicrobial drugs is a critical phenomenon that is hampering clinical treatments, raising the need for promising compounds that can be explored as pharmaceutical products.
Washington de Souza Leal, Juliane Zacour Marinho, Isabela Penna Ceravolo, Lucas Leão Nascimento, Antonio Otávio de Toledo Patrocínio, Marcus Vinícius Dias-Souza   +5 more
doaj   +1 more source

Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs

Pharmaceutics, 2011
Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs.
Jörg König, Martin F. Fromm, Sabine Klatt   +2 more
doaj   +1 more source

Clozapine treatment in patients living in the community [PDF]

, 2015
OBJECTIVE: The aim of this study was to assess clozapine treatment in the local community with respect to patient monitoring during dispensing, patient compliance through prescription refills, presence of any other existing co-morbidities and ...
Azzopardi, Lilian M., Schembri, Karl
core  

Local and global modes of drug action in biochemical networks [PDF]

, 2008
It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between
A Ma'ayan, A Petrelli, C Lengauer, DB Kell, DS Lee, DS Wishart, EC Butcher, F Matthäus, F Sams-Dodd, GV Paolini, J Barthelmes, J Raymond, JA DiMasi, JC Nacher, Jean-Marc Schwartz, JH Kim, JJ Hornberg, Jose C Nacher, M Kanehisa, MA Yıldırım, MC Fishman, MI Siegel, O Ebenhöh, P Csermely, SB Seidman, T Handorf, T Handorf, T Handorf, T Handorf, V Batagelj, Z Spiro   +30 more
core   +4 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source