Results 61 to 70 of about 10,944,767 (389)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Drug-Induced Anaphylaxis Survey in Portuguese Allergy Departments [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Drug-induced anaphylaxis is an unpredictable and potentially fatal adverse drug reaction. The aim of this study was to identify the causes of drug-induced anaphylaxis in Portugal.
Botelho, C, Castro, E, et al, Faria, E, Gaspar, A, Morais-Almeida, M, Portuguese Society of Allergology and Clinical Immunology, Rodrigues-Cernadas, J   +7 more
core  

Sodium valproate-induced necrotizing pancreatitis in a patient with bipolar mania

Telangana Journal of Psychiatry, 2021
Bipolar disorder is a chronic complex disorder that requires lifelong maintenance treatment. Sodium valproate is an effective first-line drug for bipolar mania. Adverse effects associated with valproate are typically benign, but there are serious adverse
Sripathi Santhosh Goud, Vishal Indla
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Drug-induced dermatomyositis after lacosamide: A case report. [PDF]

, 2018
Here we describe a caseof a woman who had DM after treatment withlacosamide.
Gaffney, Rebecca G., Tarazi, Meera, Werth, Victoria P.   +2 more
core   +1 more source

Hepatitis induced by noni juice from Morinda citrifolia: A rare cause of hepatotoxicity or the tip of the iceberg? [PDF]

, 2006
A 24-year-old female patient presented to her community hospital with mild elevations of serum transaminase and bilirubin levels. Because of multiple sclerosis, she was treated with interferon beta-la for 6 weeks.
Diebold, J., Gerbes, Alexander L., Gülberg, Veit, Yuece, B.   +3 more
core   +1 more source

Modifying effects of 2,4-D and Glyphosate exposures on gut-liver-adipose tissue axis of diet-induced non-alcoholic fatty liver disease in mice

Ecotoxicology and Environmental Safety, 2023
Nonalcoholic fatty liver disease (NAFLD), which is linked to western diet (WD) intake, affects 30% of the world’s population and involves the crosstalk of liver steatosis, hypertrophy/inflammation of adipose tissue and deregulation of gut microbiome ...
Guilherme R. Romualdo, Letícia Cardoso Valente, Jéssica Luri Hisano de Souza, Josias Rodrigues, Luís Fernando Barbisan   +4 more
doaj  

Hormonal Contraceptives: What if Exposed During Pregnancy?

Erciyes Medical Journal, 2019
Objective: Hormonal contraceptives are contraindicated in pregnancy. However, some women may become pregnant while using contraceptives to prevent pregnancy.
Duygun Altıntaş Aykan, Yusuf Ergün
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Drug-Induced Acute Interstitial Nephritis.

American Society of Nephrology. Clinical Journal, 2017
Drug-induced acute interstitial nephritis (DI-AIN) is a common cause of AKI, affecting about 20% of patients with unexplained AKI, and leads to CKD and ESRD ([1][1]).
D. Moledina, M. Perazella
semanticscholar   +1 more source