Results 81 to 90 of about 5,793,514 (248)

A case of imipramine-associated immune thrombocytopenia

The Turkish Journal of Pediatrics, 2009
Drug-induced immune thrombocytopenia (DITP), excluding heparin-induced thrombocytopenia, is relatively uncommon. It is characterized by drug-dependent antibodies that bind to the platelets and cause their destruction when the responsible drug is ...
Ayşe Aksoy, Erol Erduran, Yusuf Gedik
doaj  

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Characteristics of Idiosyncratic Drug-induced Liver Injury in Children

, 2011
Background: The spectrum and severity of idiosyncratic drug-induced liver injury (DILI) in children are not well established. Patients and methods: The DILIN (Drug-Induced Liver Injury Network) Prospective Study is a longitudinal multicenter study ...
Gu, Jiezhun, Robert J. Fontana, Kleiner, David E., Fontana, Robert J., Chalasani, Naga, Naga Chalasani, Lopez, M. James, M. James Lopez, Molleston, Jean P., Jean P. Molleston, Jiezhun Gu, David E. Kleiner, Drug-Induced Liver Injury Network   +12 more
core   +1 more source

Genetic Inactivation and Pharmacological Blockade of Sigma-1 Receptors Prevent Paclitaxel-Induced Sensory-Nerve Mitochondrial Abnormalities and Neuropathic Pain in Mice

Molecular Pain, 2014
Background: Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve mitochondrial alterations.
Francisco R Nieto, Cruz M Cendán, Francisco J Cañizares, María A Cubero, José M Vela, Eduardo Fernández-Segura, José M Baeyens   +6 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Surgery-induced iris abnormalities after Descemet membrane endothelial keratoplasty and their impact on postoperative clinical outcomes

, 2019
Natsuko Mori,1,2 Hideaki Yokogawa,1 Akira Kobayashi,1 Tsubasa Nishino,1,3 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan; 2Department of Ophthalmology, Saiseikai Kanazawa Hospital ...
Kobayashi A, Mori N, Yokogawa H, Sugiyama K, Nishino T   +4 more
core  

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

QT interval abnormalities: Risk factors and perioperative management in long QT syndromes and Torsades de Pointes

, 2013
Electrophysiological abnormalities of the QT interval of the standard electrocardiogram are not uncommon. Congenital long QT syndrome is due to mutations of several possible genes (genotype) that result in prolongation of the corrected QT interval ...
Kaye, Adam M., Volpi-Abadie, Jacqueline, Bensler, J. Michael, Kaye, Alan David, Diaz, James H.   +4 more
core   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Drug-Induced Glomerulopathy: A Selective Review [PDF]

, 1983
Tbe pathogenesis of drug-induced glomerular disease is becoming better understood because of recent advances in the study of glomerular physiology and metabolism. Various classes of drugs may produce nephrotoxicity.
Dumler, Francis
core   +1 more source