Results 141 to 150 of about 4,931,245 (245)

Molecular mechanisms of l-DOPA-induced dyskinesia.

, 2010
International audienceParkinson's disease (PD), a common neurodegenerative disorder caused by the loss of the dopaminergic input to the basal ganglia, is commonly treated with l-DOPA.
Bezard, Erwan, Fisone, Gilberto
core  

Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients—A Post Hoc Bayesian Analysis of the AID‐ICU Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Delirium is clinically classified into hypoactive or hyperactive motoric subtypes, which may have different responses to treatment. We assessed heterogeneity in treatment effects according to baseline motoric subtype in the AID‐ICU trial, which randomised adult ICU patients with delirium to haloperidol versus placebo.
Nina C. Andersen‐Ranberg, Lone Musaeus Poulsen, Anders Perner, Johanna Hästbacka, Matthew Morgan, Giuseppe Citerio, Stine Estrup Damby, Camilla Bekker Mortensen, Marie Oxenbøll Collet, Sven‐Olaf Weber, Anne Sofie Andreasen, Morten Bestle, Bülent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen, Kjeld Damgaard, Troels Bek Jensen, Trine Sommer, Nilanjan Dey, Ole Mathiesen, Anders Granholm   +20 more
wiley   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Traditional Chinese Medicine Interventions for Antipsychotic-Induced Extrapyramidal Symptoms: A Data Mining–Based Integrative Review of Prescription Patterns and Evidence

Neuropsychiatric Disease and Treatment
Yu Qin,1,2 Limin Gao,2 Jie Tong,3 Xirong Sun,3 Yixin Zhou11Department of Rehabilitation Medicine, Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People’s Republic of China; 2Department of ...
Qin Y, Gao L, Tong J, Sun X, Zhou Y
doaj  

Hydromorphone-induced choreiform dyskinesia in a patient with homozygous sickle cell disease: a reversible adverse effect. [PDF]

Oxf Med Case Reports
Saife S, El Masry M, Rajab I, Rahman RA, Ghobrial N.   +4 more
europepmc   +1 more source

A small molecule reduces both parkinsonism and l-dopa-induced dyskinesia in animal models of Parkinson's disease. [PDF]

Sci Transl Med
Bordbar A, Bloem B, Lloyd C, Johnston TH, Schneider JS, Bezard E, Pioli E, Li Q, Tawfeeq C, Vu Pham N, Huber G, Wu J, Hill MP, Brotchie JM, McCammon JA, Herberg FW, Taylor S, Weiner DM, Merchant K, Famili I.   +19 more
europepmc   +1 more source

Secondary parkinsonism associated with tetrabenazine: A case report. [PDF]

Dusunen Adam
Simar AS, Samanci MY, Zirh A, Yilmaz NH.
europepmc   +1 more source

Traditional Chinese Medicine Interventions for Antipsychotic-Induced Extrapyramidal Symptoms: A Data Mining-Based Integrative Review of Prescription Patterns and Evidence. [PDF]

Neuropsychiatr Dis Treat
Qin Y, Gao L, Tong J, Sun X, Zhou Y.
europepmc   +1 more source

Tardive Dyskinesia in Patients Receiving Continuous Versus Intermittent Oral Metoclopramide: A Retrospective Real World Study. [PDF]

Neurogastroenterol Motil
Russo P, Nathan R, Camilleri M.
europepmc   +1 more source

Dopamine trasporter reversal as a pathogenic mechanism for L-dopa induced dyskinesia

, 2005
L-dopa remains the most effective drug for improving motor symptoms of Parkinson's disease (PD). However, following long-term chronic treatment, the therapeutic effects of L-dopa are often accompanied by debilitating peak-dose dyskinesia.
Cheng, Christina
core