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Randomized clinical trial of topiramate for levodopa-induced dyskinesia in Parkinson's disease

Parkinsonism and Related Disorders, 2014
BACKGROUND: The antiepileptic drug topiramate reduces levodopa-induced dyskinesia without exacerbating parkinsonism in animal models. We report a randomized, double-blind, placebo-controlled crossover trial in patients with Parkinson's disease and ...
David Burn, Lewis Kass-Iliyya, Monty Silverdale   +2 more
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Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia

Drugs, 2016
Dyskinesias encompass a variety of different hyperkinetic phenomenologies, particularly chorea, dystonia, stereotypies, and akathisia. The main types of drug-induced dyskinesias include levodopa-induced dyskinesia (LID) in patients with Parkinson's disease and tardive syndrome (TS), typically present in patients with psychiatric or gastrointenstinal ...
Dhanya, Vijayakumar, Joseph, Jankovic
openaire   +2 more sources

Drug-induced dyskinesias

Current Opinion in Neurology, 2009
Recent studies have improved our knowledge of the factors responsible for the development of dyskinesias in Parkinson's disease and the associated pathophysiology. Deep brain stimulation has been shown to be effective to treat severe tardive dyskinesias.
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Pathophysiology of drug-induced dyskinesias

Neuropharmacology, 1972
Abstract The dyskinesias produced by DOPA and prolonged treatment with phenothiazines are so similar that it is tempting to propose a common mechanism for both. The following assumptions are made: (1) Dyskinesias result from excessive inhibition of caudate neurones by dopamine. 1.
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Drug Induced Dyskinesia: A Critical Review

International Pharmacopsychiatry, 2017
Tardive dyskinesia (TD) has been reported to occur after the long term administration of neuroleptics. Its prevalence has been reported to vary from 0.5-56%. However, no clear relationship is established between a particular neuroleptic, its dosage and duration of administration and the diagnosis and occurrence of TD.
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Drug-Induced Tardive Dyskinesia

1981
Drug-induced tardive dyskinesia, which occurs in the course of long-term administration of psychotropic drugs, especially neuroleptics, and persists for years even after drug removal, began to be reported in the late 1950s. Since then, more than 100 investigations on this subjects have been described.
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Pathophysiological basis of drug-induced dyskinesias in Parkinson's disease

Brain Research Reviews, 2005
Drug-induced dyskinesias (DID) represent a troublesome, dose-limiting, and common complication of long-term pharmacotherapy in Parkinson's disease (PD) patients. The pathophysiological basis and clinical nature of DID is of major interest for clinicians and neuroscientists.
Milind, Deogaonkar, Thyagarajan, Subramanian   +1 more
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Drug-Induced and Other Orofacial-Cervical Dyskinesias

Annals of Internal Medicine, 1981
Tardive dyskinesia is one of the most prevalent and disabling of the iatrogenic disorders. Characterized by involuntary movements of the orofacial-cervical musculature that develop after prolonged use of neuroleptic drugs, it is sometimes confused with other involuntary movements involving predominantly the head and neck region.
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Tardive dyskinesia, mild drug-induced dyskinesia, and drug-induced parkinsonism: risk factors and topographic distribution.

Acta neurologica Belgica, 1999
This study attempted to contribute to the subtyping of tardive dyskinesia (TD) by studying the effects of age, sex, psychiatric diagnosis and duration of illness on the severity and topographic distribution of dyskinesia, and to describe the topographic distribution of drug-induced dyskinesia (DID) and drug-induced parkinsonism (DIP) in detail by ...
M C, Akbostanci, E C, Atbaşoğlu, H, Balaban   +2 more
openaire   +1 more source

Underrecognition of tardive dyskinesia and drug-induced parkinsonism by psychiatric residents

General Hospital Psychiatry, 1992
Recognition of tardive dyskinesia (TD) and other neuroleptic, drug-induced, extrapyramidal side effects presents a major challenge in modern clinical psychopharmacology. Failure to recognize these disorders can lead to poor patient care and may contribute to societal pressure for external control of psychiatric practice.
T E, Hansen, W L, Brown, R M, Weigel, D E, Casey   +3 more
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