Results 61 to 70 of about 14,984,527 (300)

Pharmacist interventions for older adults with polypharmacy in an ambulatory geriatric clinic

Health Literacy and Communication Open
Introduction Polypharmacy is a concern among older adults. An academic medical center in northeast Ohio currently has an outpatient geriatric medicine clinic with an embedded board-certified geriatric pharmacist who performs comprehensive medication ...
Antonietta Paneccasio, Anna Bondar, Emily Fargo, Marcie Parker, Ardeshir Hashmi, Kenneth Koncilja, Gina Elder   +6 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Outcomes and drug-related admissions of cardiovascular patients in the emergency department at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

International Journal of Emergency Medicine
Introduction Cardiovascular diseases (CVDs) are the leading cause of death globally, with a rising prevalence. The increase in medications, recognized conditions, and polypharmacy has led to more drug-related problems and emergency admissions among ...
Hikma Husein, Tamrat Assefa Tadesse, Alemu Belayneh, Merahi Kefyalew, Mesfin Ayalew Tsegaye, Elias Gashaw Endegnanew, Matyas Wondwossen Elssa, Eskinder Ayalew Sisay   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Cannabis Use and Drug Related Problems Among Adolescents in 27 European Countries: The Utility of the Prevention Paradox

Nordic Studies on Alcohol and Drugs, 2014
AIMS – To study the prevalence of cannabis use and drug-related problems among European adolescents and the utility of the prevention paradox. METHODS – Survey data from the European School Survey Project on Alcohol and Other Drugs (ESPAD) in 2007 in the
Romelsjö Anders, Danielsson Anna-Karin, Wennberg Peter, Hibell Björn   +3 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Critical Contribution of Pharmacists in Optimising Medication Safety among Children: A Narrative Review [PDF]

Journal of Clinical and Diagnostic Research
Paediatric patients are particularly vulnerable to medication errors and Adverse Drug Reactions (ADRs), with the incidence of adverse drug events being three times higher in children compared to adults.
Pulkit Deswal, Mamta Farswan Singh, Sonal Setya   +2 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Correlation between geriatric ischemic stroke patient characeteristic and drug related problems

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2020
Background: Drug related problems (DRP) can cause problems in treatments of patients with ischemic stroke. Objective: This study was to determine the correlation between the characteristics of patients with ischemic stroke and the DRP.
Dhanang Prawira Nugraha, Antonius Adji Prayitno Setiadi, Yosi Irawati Wibowo   +2 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source