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Drugs Targeting Protein—Protein Interactions
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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The Therapeutic and Psychosocial Interaction in Enhancing Drug Targets
Current Drug Targets, 2018The holistic standpoint of biopsychosocial importance of mediation is crucial in the perception regarding on how the psychopharmacological agent acts. This understanding is indeed important when dealing with patient's expectation and hope, specifically during their illness and recovery process. In clinical setting, the fundamental knowledge on know-how
Ramli, Musa, Ahmad Hatim, Sulaiman
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Interactions of phytic acid with anticancer drug targets
International Journal of Computational Biology and Drug Design, 2017Inositol hexakisphosphate is known to be the phosphorous reserve in plants particularly in the seeds. Although it has been known for its anti-nutrient properties for many years, recent research shed light on its anticancer properties. Hence, the present study focuses on probable protein targets of phytic acid (PA) through computational methods ...
Amitha Joy, S. Balaji
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Ocular drug targeting by liposomes and their corneal interactions
Journal of Microencapsulation, 1999Topical drug delivery is preferred in the eye to avoid under or over medication and undesired side effects of systemic administration. In order to maintain adequate drug levels in ocular tissues, frequent drug installation is necessary in vision threatening conditions like glaucoma, corneal ulcers due to microbial infections, etc.
T, Velpandian +4 more
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Identifying Drug-Target Interactions with Decision Templates
Current Protein & Peptide Science, 2018During the development process of new drugs, identification of the drug-target interactions wins primary concerns. However, the chemical or biological experiments bear the limitation in coverage as well as the huge cost of both time and money. Based on drug similarity and target similarity, chemogenomic methods can be able to predict potential drug ...
Xiao-Ying, Yan, Shao-Wu, Zhang
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Drug-Target Interactions: Prediction Methods and Applications
Current Protein & Peptide Science, 2018Identifying the interactions between drugs and target proteins is a key step in drug discovery. This not only aids to understand the disease mechanism, but also helps to identify unexpected therapeutic activity or adverse side effects of drugs. Hence, drug-target interaction prediction becomes an essential tool in the field of drug repurposing.
Shanmugam, Anusuya +6 more
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Learning the Drug-Target Interaction Lexicon
2022Sequence-based prediction of drug-target interactions has the potential to accelerate drug discovery by complementing experimental screens. Such computational prediction needs to be generalizable and scalable while remaining sensitive to subtle variations in the inputs. However, current computational techniques fail to simultaneously
Rohit Singh +3 more
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Revealing promiscuous drug–target interactions by chemical proteomics
Drug Discovery Today, 2009The (poly-)pharmacological activities of a drug can only be understood if its interactions with cellular components are comprehensively characterized. Mass spectrometry-based chemical proteomics approaches have recently emerged as powerful tools for the characterization of drug-target interactions in samples from cell lines and tissues.
Bantscheff, M. +2 more
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Predicting Drug Target Interactions Based on GBDT
2018The research of the drug-target interactions (DTIs) is of great significance for drug development. Traditional chemical experiments are expensive and time-consuming. In recent years, many computational approaches based on different principles have been proposed gradually.
Jiyun Chen +4 more
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Protein‐interaction mapping in search of effective drug targets
BioEssays, 2005AbstractSignaling complexes and networks are being intensely studied in an attempt to discover pathways that are amenable to therapeutic intervention. A challenge in this search is to understand the effect that the modulation of a target will have on the overall function of a cell and its surrounding neighbors.
Amitabha, Chaudhuri, John, Chant
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