Results 71 to 80 of about 888,632 (296)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Drug Target Commons 2.0: a community platform for systematic analysis of drug target interaction profiles [PDF]

, 2022
Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound-target interaction profiles.
Jing Tang, Ziaur Rehman Tanoli, Zaid Alam, Alina Malyutina, Tero Aittokallio, Alok Jaiswal, Krister Wennerberg, Markus Vähä-Koskela, Balaguru Ravikumar   +8 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Predicting Drug-Target Interactions Using Drug-Drug Interactions

PLoS ONE, 2013
Computational methods for predicting drug-target interactions have become important in drug research because they can help to reduce the time, cost, and failure rates for developing new drugs. Recently, with the accumulation of drug-related data sets related to drug side effects and pharmacological data, it has became possible to predict potential drug-
Kim, Shinhyuk, Jin, Daeyong, Lee, Hyunju
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Identifying potential drug-target interactions based on ensemble deep learning

Frontiers in Aging Neuroscience, 2023
IntroductionDrug-target interaction prediction is one important step in drug research and development. Experimental methods are time consuming and laborious.MethodsIn this study, we developed a novel DTI prediction method called EnGDD by combining ...
Liqian Zhou, Yuzhuang Wang, Lihong Peng, Zejun Li, Xueming Luo   +4 more
doaj   +1 more source

Monoamine Oxidase Inhibitors – Indirect Acting Sympathomimetics - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between Monoamine Oxidase Inhibitors – Indirect Acting Sympathomimetics. The information is not advice, and should not be treated as such. The information is
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing [PDF]

, 2020
Knowledge of the full target space of drugs (or drug-like compounds) provides important insights into the potential therapeutic use of the agents to modulate or avoid their various on- and off-targets in drug discovery and precision medicine.
Wennerberg, Krister, Vähä-Koskela, Markus, Aittokallio, Tero, Ianevski, Aleksandr, Alam, Zaid, Tanoli, Ziaurrehman   +5 more
core   +1 more source

EmbedDTI: Enhancing the Molecular Representations via Sequence Embedding and Graph Convolutional Network for the Prediction of Drug-Target Interaction

Biomolecules, 2021
The identification of drug-target interaction (DTI) plays a key role in drug discovery and development. Benefitting from large-scale drug databases and verified DTI relationships, a lot of machine-learning methods have been developed to predict DTIs ...
Yuan Jin, Jiarui Lu, Runhan Shi, Yang Yang   +3 more
doaj   +1 more source