Results 81 to 90 of about 888,632 (296)

Drug Target Interaction Prediction

International Journal of Advanced Research in Science, Communication and Technology
Drug–target interaction (DTI) prediction is vital to drug discovery, assisting in the identification of drug- target protein interactions more efficiently than usual methods of experimentation, which are frequently costly and time-consuming. To In order to tackle these issues, this piece presents a web-based application that predicts DTIs and ...
null Ruby Sheikh, null Dr. Soumyasri S M
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A directed weighted network-based method for drug combinations identification using drug-target and inter-target regulation

BMC Bioinformatics
Background Drug combination is currently a promising solution in treating complex diseases due to its reducing toxicity and enhancing therapeutic efficacy. However, the accurate identification of drug combination effects remains challenging.
Shen Xiao, Yuhang Li, Jinwei Bai, Zhenhua Shen, Can Huang, Rongwu Xiang, Yuxuan Zhai, Xiwei Jiang   +7 more
doaj   +1 more source

Heterogeneous networks in drug-target interaction prediction

CoRR
23 pages, 5 figures, 10 ...
Molaee, Mohammad, Charkari, Nasrollah Moghadam, Ghaderi, Foad   +2 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

BCR-ABL Tyrosine Kinase Inhibitors (TKI) + Proton Pump Inhibitors (PPI) - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between BCR-ABL Tyrosine Kinase Inhibitors (TKI) + Proton Pump Inhibitors (PPI). The information is not advice, and should not be treated as such.
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Drug-gene interaction networks.

, 2023
Type 2 diabetes (T2D) is one of the major metabolic disorders in humans caused by hyperglycemia and insulin resistance syndrome. Although significant genetic effects on T2D pathogenesis are experimentally proved, the molecular mechanism of T2D in South ...
Md. Golam Rabby (13514311), Md. Numan Islam (13514308), Md. Mahmudul Hasan (8520969), Md. Mostafa Kamal (13514317), Mrityunjoy Biswas (708113), Md. Hafizur Rahman (7440173), Mantasa Bonny (17636492)   +6 more
core   +1 more source

SuperTarget goes quantitative: update on drug-target interactions

Nucleic Acids Research, 2011
There are at least two good reasons for the on-going interest in drug-target interactions: first, drug-effects can only be fully understood by considering a complex network of interactions to multiple targets (so-called off-target effects) including metabolic and signaling pathways; second, it is crucial to consider drug-target-pathway relations for ...
Nikolai Hecker, Jessica Ahmed, Joachim von Eichborn, Mathias Dunkel, Karel Macha, Andreas Eckert, Michael K. Gilson, Philip E. Bourne, Robert Preissner   +8 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source