Results 81 to 90 of about 2,729,950 (336)

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

EmbedDTI: Enhancing the Molecular Representations via Sequence Embedding and Graph Convolutional Network for the Prediction of Drug-Target Interaction

Biomolecules, 2021
The identification of drug-target interaction (DTI) plays a key role in drug discovery and development. Benefitting from large-scale drug databases and verified DTI relationships, a lot of machine-learning methods have been developed to predict DTIs ...
Yuan Jin, Jiarui Lu, Runhan Shi, Yang Yang   +3 more
doaj   +1 more source

Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations [PDF]

, 2015
Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side ...
A Banerjee, A Bauer-Mehren, A Franceschini, A Sharma, A Stojmirović, AF Fliri, C Knox, D Bray, D Brockmann, D Fazekas, D Parchwani, D Veres, DH Zanette, E Lounkine, H Hu, H Iwata, H Luo, HY Chuang, IW Taylor, J Serra-Musach, J Sun, J Wang, J Xia, JC Nacher, JL Oliveira, JM Schwartz, JO Rosado, KZ Szalay, KZ Szalay, L Brouwers, L Yang, L Yang, M Campillos, M Kuhn, M Takarabe, MA Antal, MA Yildirim, P Csermely, P Lopes, P Shannon, P Wang, PF Jonsson, R Nussinov, S Aral, S Lee, S Mizutani, SA Forbes, SP Cornelius, SP Wein, T Hase, TI Oprea, TW Valente, Y Yamanishi, Á Mihalik   +53 more
core   +4 more sources

MSI-DTI: predicting drug-target interaction based on multi-source information and multi-head self-attention

Briefings Bioinform.
Identifying drug-target interactions (DTIs) holds significant importance in drug discovery and development, playing a crucial role in various areas such as virtual screening, drug repurposing and identification of potential drug side effects.
Wenchuan Zhao, Yufeng Yu, Guosheng Liu, Yanchun Liang, Dong Xu, Xiaoyue Feng, Renchu Guan   +6 more
semanticscholar   +1 more source

Modified linear regression predicts drug-target interactions accurately

PLOS ONE, 2020
State-of-the-art approaches for the prediction of drug-target interactions (DTI) are based on various techniques, such as matrix factorisation, restricted Boltzmann machines, network-based inference and bipartite local models (BLM). In this paper, we propose the framework of Asymmetric Loss Models (ALM) which is more consistent with the underlying ...
Krisztian Buza, Ladislav Peška, Júlia Koller   +2 more
openaire   +4 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

GraphormerDTI: A graph transformer-based approach for drug-target interaction prediction

Comput. Biol. Medicine
The application of Artificial Intelligence (AI) to screen drug molecules with potential therapeutic effects has revolutionized the drug discovery process, with significantly lower economic cost and time consumption than the traditional drug discovery ...
Mengmeng Gao, Daokun Zhang, Yi Chen, Yiwen Zhang, Zhikang Wang, Xiao-Yong Wang, Shanshan Li, Yuming Guo, Geoffrey I. Webb, A. T. Nguyen, Lauren T. May, Jiangning Song   +11 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs

Computational and Structural Biotechnology Journal, 2020
Drug repositioning aims to find new indications for existing drugs in order to reduce drug development cost and time. Currently,there are numerous stories of successful drug repositioning that have been reported and many repurposed drugs are already ...
Daniele Parisi, Melissa F. Adasme, Anastasia Sveshnikova, Sarah Naomi Bolz, Yves Moreau, Michael Schroeder   +5 more
doaj   +1 more source