Results 71 to 80 of about 6,956,165 (310)
Zero-shot Learning of Drug Response Prediction for Preclinical Drug Screening [PDF]
arXiv, 2023 Conventional deep learning methods typically employ supervised learning for drug response prediction (DRP). This entails dependence on labeled response data from drugs for model training. However, practical applications in the preclinical drug screening phase demand that DRP models predict responses for novel compounds, often with unknown drug ...
arxiv
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
International Journal of Integrated Care, 2005 Purpose: To examine assessed need and wider health and social care service contact for a total Deliberate Self Harm (DSH) population in the UK. Methods: The study first recorded assessed needs and referrals for this population, then used a new method of ...
J. Keene
doaj +1 more source
A New Metric Quantifying Chemical and Biological Property of Small Molecule Metabolites and Drugs
Frontiers in Molecular Biosciences, 2020 One prominent class of drugs is chemical small molecules (CSMs), but the majority of CSMs are of very low druggable potential. Therefore, it is quite important to predict drug-related properties (druggable properties) for candidate CSMs.
Chuanbo Huang +4 more
doaj +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Improving Drug Safety: The Importance of Postmarking Drug Surveillance [PDF]
, 2004 Improved postmarketing surveillance system may reduce the number of adverse reactions to prescription drugs that under the current system continue to rise as the number of prescriptions written in the U.S ...
James Nyberg, Robert N. Butler
core
‘Initiation into drug use’ addendum: findings from the DUMA program [PDF]
, 2012 The age at which an individual first experiments with illicit drugs has been of significant interest to policymakers and practitioners, primarily because research has persistently shown a link between early juvenile onset of drug use and less favourable ...
Jason Payne, Josh Sweeney
core +1 more source
DARU Journal of Pharmaceutical Sciences, 2012 Editorial Active pharmaceutical ingredients (APIs) are most conveniently developed and delivered orally as solid dosage forms that contain a defined crystalline form of an API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π ...
openaire +3 more sources
Clinical connectivity map for drug repurposing: using laboratory tests to bridge drugs and diseases [PDF]
arXiv, 2020 Drug repurposing has attracted increasing attention from both the pharmaceutical industry and the research community. Many existing computational drug repurposing methods rely on preclinical data (e.g., chemical structures, drug targets), resulting in translational problems for clinical trials.
arxiv
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source