Results 71 to 80 of about 12,292,416 (404)

Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets

open access: yesBiomolecules, 2022
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as Alzheimer’s disease (AD).
Zdeněk Fišar
doaj   +1 more source

The use of drug calendars for the diagnosis of cutaneous drug eruptions in the age of electronic medical records [PDF]

open access: yes, 2020
A morbilliform drug eruption is the most common condition leading to a dermatology consultation for a patient in the hospital. Timing is an important diagnostic tool since the onset of a skin rash usually takes place within days-to-weeks of the start of ...
Cohen, Philip R, Grossman, Marc E
core  

Synergistic drug combinations from electronic health records and gene expression. [PDF]

open access: yes, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William   +19 more
core   +2 more sources

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]

open access: yes, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Drug use in the year after prison [PDF]

open access: yes, 2019
With poor health and widespread drug problems in the U.S. prison population, post-prison drug use provides an important measure of both public health and social integration following incarceration.
Simes, Jessica T., Western, Bruce
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

FUNCTIONAL ANALYSIS OF THE WEBBING USED IN AUTO SEATBELTS [PDF]

open access: yesAnnals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2016
The reason this paper was made was to identify the functions with the highest importance factor of webbing used in auto seatbelts. For these functions to satisfy all the requirements of operating, functions resulted from analyzing the properties of the ...
DRUG (LUCA) Alexandra, CIOARĂ Ioan
doaj  

Drug Cases Filed across the Alaska Court System, FY 2008–2017 [PDF]

open access: yes, 2018
Underlying data is available in both Excel and PDF format. (Download below.)This fact sheet presents data on drug-related court filings throughout the state of Alaska for the fiscal years (FY) 2008 through 2017 and the 10-year trend of misdemeanor and ...
Reinhard, Daniel
core  

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