Results 111 to 120 of about 1,886,307 (248)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial

BMC Medicine
Background This study aims to evaluate the clinical effectiveness and feasibility of a novel bilateral sequential accelerated theta-burst stimulation (BS-aTBS) protocol in treatment-resistant depression (TRD) patients, compared to a standard intermittent
Xingxing Li, Enze Tang, Lingjiang Liu, Chang Yu, Kai Chen, Yongming Xu, Zhiwang Liu, Yuanyuan Liu, Mengqi Zhao, Shuangying Wang, Zichen Ding, Nan Jiang, Ti-Fei Yuan, Dongsheng Zhou   +13 more
doaj   +1 more source

British journal of addiction.

, 1903
Contains papers read at the quarterly meetings of the society, and extracts from the discussions following them with other communications dealing with alcohol and alcoholism.Title varies slightly.Title from cover.None published July-Dec.
Society for the Study of Addiction to Alcohol and Other Drugs., Society for the Study of Inebriety (Alcoholism and Drug Addiction)   +1 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Practical skills and clinical management of alcoholism and drug addiction /

This insightful book is a synoptic presentation of Causes and Treatment of Alcoholism and Drug Addiction. It gives an insight into Alcoholism and Drug Addiction genetic and/or acquired etiologies through researched studies that draw the conclusion that ...
Obembe, Samuel B.
core  

Mobile and web-based application to get solutions from drug addiction : telepsychiatry perspective [PDF]

, 2019
Background: In recent time, telepsychiatry has brought the revolutionary changes in the treatment of mental health sector. Telepsychiatry has received most significance as it can help in saving the time, cost and visits of the victims.Objectives: The ...
Bart, Genevieve, Zhyvolozhnyi, Artem, Vainio, Seppo, Yoshii, Hatsumi, Sharma, Abhishek, Samoylenko, Anatoliy, Rushdy, Molly Afroz, Mazumder, Atiqul Haq, Mahmud, Mubashshira Tasnim, Huttula, Marko, Veijola, Juha   +10 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Perspectives on drugs: Drug consumption rooms: an overview of provision and evidence. [PDF]

, 2016
Supervised drug consumption facilities, where illicit drugs can be used under the supervision of trained staff, have been operating in Europe for the last three decades.

core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source