Results 101 to 110 of about 1,886,307 (248)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Tobacco exposure and alcohol drinking prevalence and associations with hypertension in rural southwest China: A cross-sectional study

Tobacco Induced Diseases
Introduction This study examined the prevalence of tobacco exposure and drinking and ascertained the relationships between tobacco exposure, alcohol drinking, concurrent smoking and drinking, and hypertension in rural southwestern China.
Guohui LI, Lan Liu, Du-li Liu, Zi-zi Yu, Allison R. Golden, Xiang-yang Yin*, Le Cai*   +6 more
doaj   +1 more source

Other title: Ohio Department of Alcohol and Drug Addiction Services' ... annual report; Other title: Annual report

Electronic coverage as of Mar.
Ohio. Dept. of Alcohol and Drug Addiction Services.
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Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Author Correction to: Gray-matter structure in long-term abstinent methamphetamine users

BMC Psychiatry, 2021
Lili Nie, Zeyong Zhao, Xiantao Wen, Wei Luo, Tao Ju, Anlian Ren, Binbin Wu, Jing Li   +7 more
doaj   +1 more source

Comparison of Causes of Drug Abuse from the Viewpoint of Addicted Patients and Their Families [PDF]

Background: Given the high prevalence of addiction in Iran and its social and health problems, addiction is considered as one of the few national health priority.
حیدری, حشمت اله, مالمیر, محمد شریف, کامران, عزیز, بیرانوند, نورالدین   +3 more
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Exercise addiction – the emergence of a new disorder [PDF]

, 2014
An optimal level of regular physical activity plays an important role in the maintenance of physical and mental health. However, excessive exercise in a minority of individuals can have adverse effects on health and lead to exercise addiction.
Demetrovics, Zsolt, Szabó, Attila, Berczik, K, Griffiths, MD, Kökönyei, Gyöngyi, Szabó, A, Kurimay, T, Urbán, R, Kökönyei, G, Urbán, Róbert, Demetrovics, Z, Kurimay, Tamás, Berczik, Krisztina, Griffiths, Mark   +13 more
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Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]

, 2014
This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
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