Results 81 to 90 of about 1,886,307 (248)

GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice

Translational Psychiatry
G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about its functional role in cannabinoid action and substance use disorders.
Yi He, Hui Shen, Guo-Hua Bi, Hai-Ying Zhang, Omar Soler-Cedeño, Hannah Alton, Yihong Yang, Zheng-Xiong Xi   +7 more
doaj   +1 more source

Comparing Physicians’ Job and Life Satisfaction, Psychological Well-Being, Anxiety, and Depression: Remaining in Türkiye vs. Emigrating to Other Countries

Psychiatry and Clinical Psychopharmacology
Background: The migration of educated professionals, particularly physicians, from developing to developed countries is a significant issue. This “brain drain” diminishes essential human resources in the healthcare sector of countries like Türkiye ...
Gamze Zengin İspir, Mustafa Danişman, Kübra Sezer Katar, Mustafa Batuhan Kurtoğlu   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Uncovering mechanism of hepatotoxicity diseases caused by tetrahydrocannabinol based on novel network toxicology and experimental verification

Scientific Reports
This study systematically investigated the molecular mechanisms underlying tetrahydrocannabinol (THC)-induced hepatotoxicity in humans through an integrated approach combining network toxicology, molecular docking, and experimental validation.
Tiantian Zou, Ruilin Zhang, Liping Hu, Genmeng Yang, Xuanyu Chen, Mengqing Wang, Tiantian Cheng, Shengjie Nie, Linlin Liu, Shijun Hong   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Delay, probability, and effort discounting in drug addiction

, 2020
Impulsivity is a core characteristic of substance abuse in that negative consequences of drug use are devalued in favor of the rewarding effects of the drug.
Garami, Julia K. (S32362), Ahmed A. Moustafa, Julia Garami, Moustafa, Ahmed A. (R17078)   +3 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Social poverty indicators with school bullying victimization: evidence from the global school-based student health survey (GSHS)

BMC Public Health
Background School bullying is prevalent in children and adolescents. Bullying victims are seen higher risk of negative psychological outcomes. Previously published studies suggested that social indicators may pose significant influence on bullying ...
Lin Chen, Ying Chen, Hailiang Ran, Yusan Che, Die Fang, Qiongxian Li, Yuanyu Shi, Shuqing Liu, Yandie He, Guiqing Zheng, Yuanyuan Xiao   +10 more
doaj   +1 more source

Episodic future thinking in drug addiction

, 2020
Future episodic thinking refers to the ability to imagine oneself in the future and project oneself into specific future events. This cognitive process is related to decision making and planning for the future.
Morris, Alejandro N. (S35287), Ahmed A. Moustafa, Alejandro N. Morris, Moustafa, Ahmed A. (R17078), Mohamad El Haj, El Haj, Mohamad   +5 more
core   +1 more source