Results 171 to 180 of about 4,201,815 (397)

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Predictors of concurrent heroin use among patients on opioid maintenance treatment in France: a multilevel study over 11 years

Harm Reduction Journal
Background Consistent reports from health professionals suggest that heroin is commonly used by patients undergoing opioid maintenance treatment (OMT) in France, potentially jeopardizing their recovery process.
Eric Janssen, Mike Vuolo, Stanislas Spilka, Guillaume Airagnes   +3 more
doaj   +1 more source

Mechanisms and treatments of methamphetamine and HIV-1 co-induced neurotoxicity: a systematic review

Frontiers in Immunology
Combination antiretroviral therapy (cART) has dramatically reduced mortality in people with human immunodeficiency virus (HIV), but it does not completely eradicate the virus from the brain.
Lin Miao, Haowei Wang, Yi Li, Jian Huang, Chan Wang, Hanxin Teng, Lisha Xu, Xue Yang, Yunqing Tian, Genmeng Yang, Juan Li, Xiaofeng Zeng   +11 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

New Drugs of Addiction [PDF]

, 1965
P. A. L. Chapple
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Characterization of ibogaine analogs on the hα3β4 nicotinic acetylcholine receptor. [PDF]

, 2012
Nicotine addiction is a global health problem that affects nearly one-third of the population. Animal models have shown that the beta-4 subunit of nicotinic acetylcholine receptors (nAChR) expressed in the habenulointerpeduncular pathway plays a ...
Ross, Jordan
core  

Editorial: Stress, pain or drug addiction: epigenetics, biological mechanisms and therapeutics. [PDF]

Front Mol Neurosci, 2023
Kim HY, Shim I.
europepmc   +1 more source

Addiction to Morphia and Allied Drugs Some Recent Developments

, 1954
A Spencer Paterson
openalex   +1 more source

Forensic Medicine and Toxicology: Drug Addiction [PDF]

, 1967
T. H. Bewley
openalex   +1 more source