Results 71 to 80 of about 4,201,815 (397)
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
What Does America Think About Addiction Prevention and Treatment? [PDF]
, 2007 Summarizes survey results on how Americans view alcohol and drug addiction, including whether it is a personal weakness or an illness; their experiences with addiction; common treatments; and support for state tax increases to improve treatment ...
Deanna Lewis
core
How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction. [PDF]
, 2015 Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained despite adverse consequences and intense drug craving.
Belin, David +3 more
core +2 more sources
Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma.
Cancer Discovery, 2018 Melanoma resistant to MAPK inhibitors (MAPKi) displays loss of fitness upon experimental MAPKi withdrawal and, clinically, may be resensitized to MAPKi therapy after a drug holiday. Here, we uncovered and therapeutically exploited the mechanisms of MAPKi
Aayoung Hong +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
Age Differences in Psychoactive Substance Abuse in Population of the Republic of Belarus
Central European Journal of Sport Sciences and Medicine, 2016 Background. The recent epidemiological studies conducted in Belarus point to a fall in the average age of registered drug abusers and in the age of drug use onset, an increasing proportion of injecting drugs, and addicted persons.
Vladimir Lelevich +3 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Cancer Drug Addiction is Relayed by an ERK2-Dependent Phenotype Switch
Nature, 2017 Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment ...
X. Kong +10 more
semanticscholar +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
University Scholar Series: Laurie Drabble [PDF]
, 2010 Alcohol and Drug Addiction Among Marginalized Populations of Women On September 29, 2010 Laurie Drabble spoke in the University Scholar Series hosted by Provost Gerry Selter at the Dr. Martin Luther King, Jr. Library.
Drabble, Laurie A
core +1 more source