Results 11 to 20 of about 9,077,301 (404)

Reporting Bias in Drug Trials Submitted to the Food and Drug Administration: Review of Publication and Presentation [PDF]

PLoS Medicine, 2008
BackgroundPrevious studies of drug trials submitted to regulatory authorities have documented selective reporting of both entire trials and favorable results.
Lisa Bero
exaly   +5 more sources

Intracerebroventricular drug administration

Translational and Clinical Pharmacology, 2017
Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood-brain barrier readily.
A. Atkinson
openaire   +3 more sources

Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs

Drug Metabolism And Disposition, 2022
The market for large molecule biologic drugs has grown rapidly, including antisense oligonucleotide (ASO) drugs. ASO drugs work as single-stranded synthetic oligonucleotides that reduce production or alter functions of disease-causing proteins through ...
Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P Rasmussen, R. Bahal, Xiao-bo Zhong, J. Manautou   +7 more
semanticscholar   +1 more source

The contribution of smoking-attributable mortality to differences in mortality and life expectancy among US African-American and white adults, 2000-2019

Demographic Research, 2022
Background: The role of smoking in racial disparities in mortality and life expectancy in the United States has been examined previously, but up-to-date estimates are generally unavailable, even though smoking prevalence has declined in recent decades.
Brian L. Rostron, Cindy M. Chang, Brittny C. Davis Lynn, Chunfeng Ren, Esther Salazar, Bridget K. Ambrose   +5 more
doaj   +1 more source

Comparison of Amitriptyline and US Food and Drug Administration–Approved Treatments for Fibromyalgia

JAMA Network Open, 2022
This systematic review and network meta-analysis compares amitriptyline with Food and Drug Administration–approved treatments for fibromyalgia related to sleep, fatigue, and health-related quality of life outcomes.
H. M. Farag, Ismaeel Yunusa, H. Goswami, I. Sultan, J. Doucette, T. Eguale   +5 more
semanticscholar   +1 more source

Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs

Drug Metabolism And Disposition, 2022
Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes for determination of a drug’s pharmacokinetic parameters, which have direct impacts on efficacy and adverse drug reactions (ADRs).
Julia M. Migliorati, Sunna Liu, A. Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P Rasmussen, J. Manautou, Xiao-bo Zhong   +8 more
semanticscholar   +1 more source

Food and Drug Administration

Definitions, 2020
The Food and Drug Administration is responsible for maintaining a national program to protect the public health from unnecessary and harmful radiation emitted by radiation products.
Arif Subhan
semanticscholar   +1 more source

Anticancer Drugs Approved by the US Food and Drug Administration From 2009 to 2020 According to Their Mechanism of Action

JAMA Network Open, 2021
Key Points Question How often are anticancer drugs approved based on a new mechanism of action? Findings In this cross-sectional study of 332 US Food and Drug Administration–approved anticancer drugs from 2009 to 2020, 16% of approvals were based on a ...
T. Olivier, A. Haslam, V. Prasad
semanticscholar   +1 more source

The Options for Neuraxial Drug Administration

CNS Drugs, 2022
Neuraxial drug administration, i.e., the injection of drugs into the epidural or intrathecal space to produce anesthesia or analgesia, is a technique developed more than 120 years ago.
H. Hermanns, Elke M E Bos, M. L. van Zuylen, M. Hollmann, M. Stevens   +4 more
semanticscholar   +1 more source

Dimensional variability characterization of additively manufactured lattice coupons

3D Printing in Medicine, 2022
Background Additive manufacturing (AM), commonly called 3D Printing (3DP), for medical devices is growing in popularity due to the technology’s ability to create complex geometries and patient-matched products.
Kirstie Lane Snodderly, Magdalene Fogarasi, Yutika Badhe, Ankit Parikh, Daniel Porter, Albert Burchi, Laura Gilmour, Matthew Di Prima   +7 more
doaj   +1 more source