Results 201 to 210 of about 2,902,189 (362)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Beyond business as usual for lymphatic filariasis mass drug administration in hotspot districts. [PDF]

Int Health
de Souza DK, Sumboh JG, Laryea NA, Asiedu O, Alomatu B, Mensah SK, Otchere J, Opare JL, Ahorlu CS.   +8 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Author Correction: Regulatory review of benefits and risks of preventing infant RSV disease through maternal immunization

npj Vaccines
Yugenia K. Hong-Nguyen, Joseph Toerner, Lucia Lee, Maria C. Allende, David C. Kaslow   +4 more
doaj   +1 more source

Effect of short- and long-term administration of some anticonvulsant drugs on the folate content of rat brain [proceedings].

, 1978
Steven J. Cooke, James Crossland
openalex   +1 more source

Development of a Two-Dimensional Compatibility Table for Intravenous Y-Site Drug Administration in a Neonatal Intensive Care Unit

, 2020
이선민
openalex   +1 more source

Increased GABA_Breceptor function in mouse frontal cortex after repeated administration of antidepressant drugs or electroconvulsive shocks [PDF]

, 1987
Julian Gray, A. Richard Green
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Rapid Systematic Review of U.S. Food and Drug Administration-authorized COVID-19 Treatments. [PDF]

Open Forum Infect Dis
Sullivan DJ, Franchini M, Joyner MJ, Casadevall A, Focosi D.   +4 more
europepmc   +1 more source

The Food and Drug Administration as Gatekeeper and the Menthol Exemption

, 2020
Micah L. Berman, Desmond Jenson
openalex   +2 more sources