d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada+3 more
wiley +1 more source
The effects of chronic drug administration on hepatic enzyme induction and folate metabolism. [PDF]
Demetre Labadarios+4 more
openalex +1 more source
Evaluation of intranasal delivery route of drug administration for brain targeting
F. Erdő+4 more
semanticscholar +1 more source
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
A STUDY OF THE FACTORS AFFECTING THE SLEEPING TIME FOLLOWING INTRACEREBROVENTRICULAR ADMINISTRATION OF PENTOBARBITONE SODIUM: EFFECT OF PRIOR ADMINISTRATION OF CENTRALLY ACTIVE DRUGS [PDF]
Ian H. Stevenson, Michael J. Bull
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Functional parameters of spermatozoa obtained by a new selection device
This study compares density gradient centrifugation and the LensHooke CA0™ device for sperm separation. DGC requires multiple steps, specialized equipment, and technical expertise. In contrast, the CA0 device offers key practical and methodological advantages, resulting in a faster, simpler, and more affordable sperm selection method.
Julio C. Chávez+8 more
wiley +1 more source
A general equation for the ratio of the areas below the blood or plasma concentration time‐curves following intravenous and oral drug administration and its application to inter‐subject variations in drug elimination. [PDF]
DP Vaughan, A. Trainor
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Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang+6 more
wiley +1 more source