Results 71 to 80 of about 7,897,516 (385)

Mechanisms and Clinical Significance of Pharmacokinetic-Based Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration in 2017

Drug Metabolism And Disposition, 2018
Pharmacokinetic-based drug-drug interaction (DDI) data for drugs approved by the U.S. Food and Drug Administration in 2017 (N = 34) were analyzed using the University of Washington Drug Interaction Database. The mechanisms and clinical relevance of these
Jingjing Yu, I. Petrie, R. Levy, I. Ragueneau-Majlessi   +3 more
semanticscholar   +1 more source

Investigation of thrombin concentration at the time of clot formation in simultaneous thrombin and fibrin generation assays

Scientific Reports
Thrombin generation (TG) and fibrin clot formation represent the central process of blood coagulation. Up to 95% of thrombin is considered to be generated after the clot is formed. However, this was not investigated in depth.
Ivan D. Tarandovskiy, Stepan S. Surov, Leonid A. Parunov, Yideng Liang, Wojciech Jankowski, Zuben E. Sauna, Mikhail V. Ovanesov   +6 more
doaj   +1 more source

Recovery and growth potential of Listeria monocytogenes in temperature abused milkshakes prepared from naturally contaminated ice cream linked to a listeriosis outbreak

Frontiers in Microbiology, 2016
The recovery and growth potential of Listeria monocytogenes was evaluated in three flavors of milkshakes (vanilla, strawberry, and chocolate) that were prepared from naturally contaminated ice cream linked to a listeriosis outbreak in the U.S.
Yi eChen, Emma eAllard, Anna eWooten, Minji eHur, Ishani eSheth, Anna eLassri, Thomas S Hammack, Dumitru eMacarisin   +7 more
doaj   +1 more source

Advancing digital health: FDA innovation during COVID-19

npj Digital Medicine, 2020
Digital health products have played an important role in the COVID-19 response, from supporting the remote monitoring of patients to enabling continuity in data collection for clinical trials. The U.S.
Kushal Kadakia, Bakul Patel, Anand Shah
doaj   +1 more source

Elimination of lymphatic filariasis: current perspectives on mass drug administration

Research and Reports in Tropical Medicine, 2018
Following the London declaration on neglected tropical diseases (NTDs) in 2012 and inspired by the WHO 2020 roadmap to control or eliminate NTDs, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) intensified preventive chemotherapy and ...
J. Gyapong, I. Owusu, F. D. da-Costa Vroom, E. Mensah, M. Gyapong   +4 more
semanticscholar   +1 more source

Regulatory implications of ctDNA in immuno-oncology for solid tumors

Journal for ImmunoTherapy of Cancer, 2023
In the era of precision oncology, use of circulating tumor DNA (ctDNA) is emerging as a minimally invasive approach for the diagnosis and management of patients with cancer and as an enrichment tool in clinical trials.
Harpreet Singh, Richard Pazdur, Paz J Vellanki, Soma Ghosh, Anand Pathak, Michael J Fusco, Erik W Bloomquist, Shenghui Tang, Reena Philip, Julia A Beaver   +9 more
doaj   +1 more source

Molecular Substructure-Aware Network for Drug-Drug Interaction Prediction [PDF]

arXiv, 2022
Concomitant administration of drugs can cause drug-drug interactions (DDIs). Some drug combinations are beneficial, but other ones may cause negative effects which are previously unrecorded. Previous works on DDI prediction usually rely on hand-engineered domain knowledge, which is laborious to obtain.
arxiv  

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

PLoS Medicine, 2008
Background Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance.
I. Kirsch, B. Deacon, Tania B. Huedo-Medina, A. Scoboria, T. Moore, Blair T. Johnson   +5 more
semanticscholar   +1 more source

Enhancing the incorporation of the patient’s voice in drug development and evaluation

Research Involvement and Engagement, 2018
Plain English summary People living with a condition are uniquely positioned to inform the understanding of the therapeutic context for drug development and evaluation. In 2012, the U.S.
Meghana Chalasani, Pujita Vaidya, Theresa Mullin   +2 more
doaj   +1 more source

Extracting Adverse Drug Events from Clinical Notes [PDF]

American Medical Informatics Association (AMIA)-2021 Virtual Informatics Summit, 2021
Adverse drug events (ADEs) are unexpected incidents caused by the administration of a drug or medication. To identify and extract these events, we require information about not just the drug itself but attributes describing the drug (e.g., strength, dosage), the reason why the drug was initially prescribed, and any adverse reaction to the drug.
arxiv