Results 71 to 80 of about 2,902,189 (362)

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Regulatory review of benefits and risks of preventing infant RSV disease through maternal immunization

npj Vaccines
In August 2023, FDA approved Abrysvo for active immunization of pregnant individuals at 32 through 36 weeks gestational age to prevent lower respiratory tract disease (LRTD), including severe LRTD, caused by respiratory syncytial virus (RSV) in infants ...
Yugenia K. Hong-Nguyen, Joseph Toerner, Lucia Lee, Maria C. Allende, David C. Kaslow   +4 more
doaj   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel [PDF]

, 2015
By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics ...
A Danso-Appiah, A Fenwick, A Montresor, A Vidyashankar, AC Gelman, AE Butterworth, AL Bustinduy, Alexandra U. Scherrer, AU Scherrer, B Levecke, BM Bolker, CH King, Charles H. King, CJL Murray, CL Black, D Alonso, D Bates, F Thiongo, G Raso, Giovanna Raso, GR Olds, IM Silva, J Cabaret, J Modha, J Smith, J Utzinger, J Utzinger, J Utzinger, J. Russell Stothard, JA Hanley, JC Sousa-Figueiredo, JD Hadfield, Jean T. Coulibaly, José Carlos Sousa-Figueiredo, JP Webster, JT Coulibaly, Jürg Utzinger, K Stete, Katarina Stete, M Albonico, M Booth, M Ismail, M Nielsen, M Reddy, M Walker, Maria-Gloria Basáñez, Martin Walker, ME Mejía, MEJ Woolhouse, MG Basáñez, MJ Bockarie, MJ Doenhoff, MJ Doenhoff, P Andrews, P Fallon, PH Lamberton, Piero L. Olliaro, PJ Brindley, PJ Diggle, PJ Hotez, PL Olliaro, PNM Mwinzi, R Core Team, S Anayi, SD Melman, SJ Vlas de, SN Lahiri, SV Subramanian, Tarub S. Mabud, TW Jia, U Halekoh, W Harnett, W Wang, World Health Organization, World Health Organization, World Health Organization   +75 more
core   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mass drug administration campaigns: Comparing two approaches for schistosomiasis and soil-transmitted helminths prevention and control in selected southern Malawi districts [PDF]

, 2022
Peter Makaula, Sekeleghe A. Kayuni, Kondwani Chidzammbuyo Mamba, Grace Bongololo, Mathias Funsanani, Lazarus Juziwelo, Janelisa Musaya, Peter Furu   +7 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Public feedback to FDA on regulatory considerations for AI in drug manufacturing

AAPS Open
FDA’s Center for Drug Evaluation and Research (CDER) established the Framework for Regulatory Advanced Manufacturing Evaluation (FRAME) initiative to establish a regulatory framework to support the adoption of advanced manufacturing technologies that ...
Jayanti Das, Thomas F. O’Connor, Adam C. Fisher, Manuel Osorio, Johnny Lam, Riley C. Myers   +5 more
doaj   +1 more source

Deadly in Pink: Big Tobacco Steps Up Its Targeting of Women and Girls [PDF]

, 2009
Outlines the tobacco industry's marketing campaigns targeting women and girls, with examples of advertisements and the effects on women's health.

core