Results 81 to 90 of about 286,603 (310)

Optimization and Dose Estimation of Aerosol Delivery to Non-Human Primates [PDF]

, 2016
Background: In pre-clinical animal studies, the uniformity of dosing across subjects and routes of administration is a crucial requirement. In preparation for a study in which aerosolized live-attenuated measles virus vaccine was administered to ...
Amerongen, G. (Geert) van, Duprex, W.P. (William Paul), Fink, J.B. (James B.), Janssens, H.M. (Hettie), MacLoughlin, R.J. (Ronan J.), Swart, R.L. (Rik) de   +5 more
core   +2 more sources

High Healthcare Utilization Preceding Diagnosis with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective Though early diagnosis improves long‐term outcomes, Juvenile Idiopathic Arthritis (JIA) patients often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize healthcare utilization in the year preceding diagnosis.
Anna Costello, Rui Xiao, Xuemei Zhang, Jahan Jazayeri, Irit R Rasooly, Pamela F Weiss   +5 more
wiley   +1 more source

Analysis and comparison of adverse events of colistin administered by different routes based on the FAERS database

Scientific Reports
Objective: To analyze and compare the incidence of adverse events (AEs) associated with different administration routes of colistin, with the aim of providing a reference for its safe and effective clinical use.
Pengtao Xu, Lili Xu, Hui Ji, Yibo Song, Keying Zhang, Xiuying Ren, Zhihua Tang   +6 more
doaj   +1 more source

Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy [PDF]

, 2017
The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and ...
Barcelona, Pablo Federico, Galan, Alba, Jian, Yifan, Nedev, Hinyu, Saragovi, H. Uri, Sarunic, Marinko V.   +5 more
core   +1 more source

Handbook of Establishing and Maintaining Oxygen‐Free Atmospheres

Advanced Engineering Materials, EarlyView.
This study presents a practical framework for creating oxygen‐free atmospheres at ambient pressure using silane‐doped inert gases. The results show that ultra‐low oxygen levels and strongly reduced water content can be achieved through controlled silane dosing, drying systems, and sensor monitoring.
Sascha Jan Zimmermann, René Gustus, Lienhard Wegewitz, Wolfgang Maus‐Friedrichs   +3 more
wiley   +1 more source

Adverse events in different administration routes of semaglutide: a pharmacovigilance study based on the FDA adverse event reporting system

Frontiers in Pharmacology
BackgroundWith the continuously increasing incidence of type 2 diabetes, glucagon-like peptide-1 (GLP-1) receptor agonists, known for their dual benefits of effectively controlling blood glucose levels while also reducing weight and lowering ...
Kaibin Niu, Maoxia Fan, Wulin Gao, Chen Chen, Guohua Dai   +4 more
doaj   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Electrochemotherapy with intravenous, intratumoral, or combined administration of bleomycin in the treatment of colorectal hepatic metastases in a rat model

Scientific Reports
Electrochemotherapy (ECT) combines the reversible electroporation (rEP) with intravenous (i.v.) or intratumoral (i.t.) administration of chemotherapeutic drugs. We conducted this study to compare the efficacy of i.v., i.t., and i.v. + i.t.
Antonios E. Spiliotis, Sebastian Holländer, Gudrun Wagenpfeil, Robert Eisele, Spyridon Nika, Orestis Mallis Kyriakides, Matthias W. Laschke, Michael D. Menger, Matthias Glanemann, Gereon Gäbelein   +9 more
doaj   +1 more source

Commercial hydrogel product for drug delivery based on route of administration

Frontiers in Chemistry
Hydrogels are hydrophilic, three-dimensional, cross-linked polymers that absorb significant amounts of biological fluids or water. Hydrogels possess several favorable properties, including flexibility, stimulus-responsiveness, versatility, and structural
Amin Raeisi, Amin Raeisi, Fatemeh Farjadian   +2 more
doaj   +1 more source

Can abuse deterrent formulations make a difference? Expectation and speculation

Harm Reduction Journal, 2009
It is critical that issues surrounding the abuse and misuse of prescription opioids be balanced with the need for these medications for the treatment of pain.
Grimes Serrano Jill M, Budman Simon H, Butler Stephen F   +2 more
doaj   +1 more source